Meir Medical Center

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Malnutrition in Maintenance Dialysis: From Metabolic Disorder to Multisystem Complications

Malnutrition and protein-energy wasting (PEW) are closely related yet distinct clinical entities. While malnutrition broadly refers to nutritional deficits arising primarily from inadequate dietary intake, PEW is a complex syndrome specific to chronic kidney disease characterized...

Eyeballing for Frailty Assessment in Elderly Patients Referred for Coronary Angiography

BACKGROUND: Frailty is increasingly recognized as a key determinant of outcomes in elderly patients undergoing invasive cardiac procedures. While structured instruments such as the Fried test are recommended, frailty is often assessed intuitively by physicians using eyeballing. W...

Lytic bone lesions in a patient diagnosed with breast cancer – Sarcoidosis

Abstract Sarcoidosis is an inflammatory disease of unknown cause with protean manifestations and presentations which may affect almost any organ. Involvement of intra-thoracic organs (lungs, lymph nodes), reticuloendothelial system, skin, and eyes is predominant. The histological...

Beyond HAS-BLED in very elderly patients with atrial fibrillation treated with direct oral anticoagulants: predictors of major bleeding in a real-world cohort

Bleeding risk assessment in very elderly patients with atrial fibrillation (AF) receiving direct oral anticoagulants (DOACs) remains challenging. The HAS-BLED score is widely used but may have limited applicability in this population. We aimed to evaluate its performance and to i...