Meiji Pharmaceutical University

Automated quantification of spinal axis distortion for behavioral assessment after spinal cord injury in mice

Spinal cord injury (SCI) causes persistent locomotor deficits that are commonly evaluated in mouse SCI models using observational scoring systems such as the Basso Mouse Scale, which primarily assesses hindlimb function. Here, we established an automated behavioral analysis pipel...

Important potential risks not reflected in Japanese drug labeling: implications for risk management plan termination

BACKGROUND: Risk management plans (RMPs) support lifecycle management of drug-related risks. In Japan, however, their use in clinical practice remains limited, and healthcare professionals often rely on the package insert for safety information. After RMP termination at re-examin...

Body Mass Index-Related Trends in Adverse Events with Enfortumab Vedotin: Analysis of a Pharmacovigilance Database and Medical Records

Abstract Background Enfortumab vedotin (EV) is an antibody–drug conjugate used to treat advanced urothelial carcinoma. Although EV therapy is effective, adverse events—particularly skin disorders—pose a challenge to optimal treatment. Previous reports suggest that body mass index...