Medizinische Hochschule Brandenburg Theodor Fontane

Th2/Th17 Inflammation: Pathogenic Drivers and Therapeutic Targets in Darier and Hailey‐Hailey Diseases

ABSTRACT Background The inherited acantholytic dermatoses Darier disease (DD) and Hailey‐Hailey disease (HHD) are characterized by a barrier dysfunction of the epidermis susceptible to inflammation and microbial infections. Objectives This study aimed at investigating the express...

From innovation to integration: what German mental health professionals think about peer-led youth discovery colleges

Abstract Mental health challenges among children and adolescents are increasing in Germany, highlighting the need for innovative, recovery-oriented approaches that complement existing mental health services. Discovery Colleges (DCs), a youth adaptation of the Recovery College mod...

“Then you are left on your own”: barriers to guideline-based speech and language therapy for aphasia along the patient journey in the German-speaking healthcare context

Abstract Background Although evidence-based recommendations for aphasia rehabilitation exist, guideline-based speech and language therapy is still not consistently implemented in routine care. Previous studies have described barriers to therapy participation from the perspective...

Validation of the German Version of the Creative Imagination Scale (CIS) in Individuals with Mild to Moderate Depressive Symptoms: A Comparison with the HGSHS-5:G

Imaginative suggestibility is an important component of hypnotic responsiveness. However, a validated German version of the Creative Imagination Scale (CIS) is lacking. This study aimed to evaluate the psychometric properties and convergent validity of the German CIS against the...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Re-opening to the world: recovery and trust

Background There is a lack of research on the experience of environmental influences and atmospheres in the recovery process of persons diagnosed with schizophrenia. So far, phenomenological approaches have only rarely been applied to study the connection between environmental ef...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Systemic influences on orthodontic tooth movement: mechanisms and clinical implications

Orthodontic tooth movement (OTM) is a complex biological process involving bone remodeling, which can be significantly affected by systemic diseases and systemic factors. This review comprehensively examines how systemic conditions such as diabetes mellitus, thyroid dysfunction,...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...

Biomarkers of systemic disease burden and outcomes after transcatheter tricuspid edge-to-edge repair

Abstract Background Risk stratification after transcatheter tricuspid edge-to-edge repair (T-TEER) remains challenging, particularly in patients with advanced right-sided heart failure and systemic disease burden. Biomarkers reflecting inflammation, stress response and multiorgan...