Medicon Village

ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner

Abstract ESR1 mutations are a driver of endocrine therapy resistance in breast cancer, however their impact on protein signaling pathways and clinical outcomes remains poorly understood. We analyzed the transcriptomic, proteomic, and phosphoproteomic landscape of tumors harboring...

Comparative Analysis of Test Methods for Predicting Dermal Sensitization Potency in Essential Oils: A Component-Based Prediction Model, GARDskin Dose–Response Assay, and Local Lymph Node Assay

The dose–response adaptation of the genomic allergen rapid detection for skin sensitizers (GARDskin DR) assay is a non-animal method for predicting sensitization potency. This proof-of-concept comparative analysis evaluates outputs from a component-based prediction model (CP), GA...