Medical University Plovdiv

Ga3+ Replacing of Fe3+ as a “Trojan Horse” Antimicrobial Strategy: Modeling the Process within Bacterial Catalase–Peroxidase KatG

Abstract Replacement of Fe3+ by Ga3+ has emerged as a promising “Trojan horse” antimicrobial strategy in response to the growing threat of antibiotic-resistant bacteria. Because many bacterial proteins hijack host iron to sustain essential redox processes, substitution with redox...

Efficacy and Safety of Remogliflozin in Adults with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis

Introduction: Remogliflozin is a sodium–glucose cotransporter-2 inhibitor used for type 2 diabetes mellitus (T2DM), but its overall efficacy and safety remain fragmented. This updated systematic review and meta-analysis evaluated the efficacy and safety of remogliflozin using evi...

Evaluation of Anthranilamide Derivatives on Learning and Memory Processes in Naïve Rats: In Silico Predictions and In Vivo Behavioral Profiling

Background: Anthranilamides have attracted increasing attention due to their antispasmodic and anti-inflammatory effects. The present study aimed to comparatively evaluate the effects of three previously synthesized anthranilamides, namely 2-chloro-N-(2-(phenethylcarbamoyl)phenyl...

Hydrothermal Aging, Thickness, and Shade as Determinants of the Optical Performance of CAD/CAM Ultra-Translucent Multilayer Zirconia Veneers

Background: Ultra-translucent multilayer zirconia is increasingly used for minimally invasive esthetic restorations, but the influence of hydrothermal aging on the translucency of veneers of different shades and thicknesses, and its possible clinical relevance, remain insufficien...

Prenatally Detected Neonatal Neuroblastoma Associated with Achondroplasia and an SDHA Variant

Background: Neuroblastoma is the most common extracranial solid tumor in infancy and demonstrates marked clinical heterogeneity. To our knowledge, this is one of the very few reported cases of neonatal neuroblastoma associated with genetically confirmed achondroplasia and an addi...

Association of admission LDL cholesterol with clinical profile and 3-months outcomes after ischaemic stroke

Abstract Background and aim We investigated whether admission LDL-C levels are associated with clinical profile and outcomes after acute ischaemic stroke by comparing patients stratified into five LDL-C groups. Patients and methods We retrospectively analyzed consecutively includ...

Divergent Immune and Endothelial Responses to Insulin Resistance in Women with Polycystic Ovary Syndrome

Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine–metabolic disorder commonly associated with insulin resistance and early cardiovascular dysfunction. Soluble CD40 ligand (sCD40L) and soluble E-selectin (sE-selectin) are circulating markers reflecting immune...

Premarital Preventive Examinations and Access to Genetic Counselling in the South-Central Region of Bulgaria: Implications for Preconception and Child Health

Background: Premarital medical certification is required before civil marriage in Bulgaria, but little is known about how newly married couples perceive this process within the broader framework of preconception care and genetic counselling. This study examined couples’ perceptio...

Uric Acid as a Redox Switch in Gout: Linking Xanthine Oxidoreductase-Derived ROS, NLRP3 Inflammasome Activation and Emerging Ferroptotic Mechanisms

Gout is a crystal-induced inflammatory arthritis driven by hyperuricemia and monosodium urate (MSU) crystal deposition, yet urate burden alone does not explain why only a subset of hyperuricemic individuals develops clinical disease, why acute flares are usually self-limited, or...

JAK2 V617F Clonal Dynamics from Clonal Hematopoiesis to Myeloproliferative Neoplasms: A Systems Biology Review of Digital PCR-Based Molecular Monitoring

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-associated premalignant state defined by somatic mutations in hematopoietic cells at a variant allele frequency (VAF) ≥2% in the absence of overt hematologic malignancy. Among CHIP-associated mutations, JAK2 V617F i...