Medical University of Białystok

Transoral robotic versus laser surgery for cT1-T3 supraglottic laryngeal cancers: a systematic review and meta-analysis of comparative and non-comparative studies

Background To compare literature findings about functional, oncological and surgical outcomes of transoral robotic (TORS) versus transoral laser microsurgery (TOLM) for supraglottic cT1-T3 laryngeal cancers. Methods Three independent investigators conducted a PubMed, Scopus, and...

The role of matrix metalloproteinases in Alzheimer's disease and small vessel disease

Matrix metalloproteinases (MMPs) are a family of enzymes participating in maintenance and remodeling of the extracellular matrix. Their many types are involved in diverse, sometimes contrasting physiological processes, and they are ubiquitously present throughout the CNS. In this...

Association of Long-Term Residentially Assigned Speciated Atmospheric Mercury Emission Flux with All-Cause and Cause-Specific Mortality

Abstract Mercury (Hg) is a persistent global pollutant, but population evidence on residentially assigned species-specific atmospheric Hg emission flux and mortality is limited. We analyzed UK Biobank cohorts for all-cause/other-cause (N = 322,666), cardiovascular disease (N = 34...

Left Atrial Appendage Closure Versus Oral Anticoagulation for Prevention of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: An Updated Meta‐Analysis of 7004 Patients Across Six Randomized Trials

ABSTRACT Introduction Left atrial appendage closure (LAAC) is an emerging alternative for stroke prevention in patients with atrial fibrillation (AF) who are unsuitable for long‐term oral anticoagulants (OACs). However, its efficacy and safety relative to OACs remain uncertain. M...

A multimodal model of aqueous humor small RNA and clinical features shows limited discrimination between primary open-angle and pseudoexfoliative glaucoma

Abstract Glaucoma is a leading cause of irreversible blindness worldwide and encompasses diseases with different clinical presentations, including primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). We investigated whether smallRNA profiles in aqueous humor,...

The Paradox of Medical Education: Lifestyle and the Sense of Self-Efficacy and Locus of Health Control Among Medical Students in the Eastern Borderlands of the European Union

Abstract Aim This cross-sectional study evaluated health behaviors, diet, physical activity, and psychological determinants (self-efficacy, life satisfaction, health locus of control) among medical and health sciences students across seven EU borderland countries to investigate t...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Distinct Determinants of Hospitalisation and In-Hospital Mortality After Acute Stroke: Insights into Stroke–Heart Syndrome (SHS-PARTICLES Study)

Background/Objectives: Stroke–heart syndrome (SHS) involves myocardial injury, cardiac dysfunction, and arrhythmias after acute stroke, playing a key role in prognosis. Most evidence comes from acute ischaemic stroke (IS), while cardiac involvement after haemorrhagic stroke (HS)...

Tryptophan Metabolism in Pediatric Atopic Dermatitis: Shared Mechanisms, Age-Specific Biomarkers, and Emerging Therapies

Atopic dermatitis affects up to one in five children; however, most mechanistic evidence linking tryptophan metabolism to disease pathogenesis derives from adult cohorts and preclinical models. Whether these mechanisms operate similarly across pediatric developmental stages remai...

Subjective Workload Perception and Coping Strategies: A Cross-Sectional Study of Polish Nurses

Background/Objectives: Subjective workload perception is an important occupational factor associated with nurses’ well-being, job satisfaction, and the quality of healthcare delivery. This study aimed to assess subjective workload perception in Polish nurses, identify their prefe...

Cardiac Electro-structural Remodeling and Arrhythmia Risks Across the Spectrum of Obesity Defined by the New Lancet framework

Abstract Background Obesity is linked to higher arrhythmia risk, yet BMI overlooks its complexity. Recently, the Lancet Commission has introduced a new obesity framework. We aimed to compare arrhythmia risks across distinct obesity categories. Methods Participants from the UK Bio...

Oxidized-Lipid Signaling and Ferroptosis as Downstream Mechanisms of Titanium-Associated Peri-Implant Bone Loss

Titanium and its alloys remain the dominant materials in oral implantology, but degradation products released through corrosion, tribocorrosion, and wear are biologically active. This critical narrative review examines oxidized-lipid signaling and ferroptosis as candidate downstr...

Cellular and Humoral Immune Responses in Anti-N Seropositive and Seronegative Vaccinated Participants: Insights from the Bialystok PLUS Study

Background: In the post-pandemic era, SARS-CoV-2 immunity is increasingly shaped by vaccination and previous infection. Understanding the relationship between cellular and humoral immune responses is important for characterizing immunity in vaccinated populations. Methods: This s...

The Inflamed Intestinal Barrier as a Formulation Variable in Oral Nanocarrier Design: Evidence-Informed Principles for Mucus Interaction, Epithelial Access, and Translational Testing

Oral nanocarrier development for inflammatory bowel disease (IBD) is complicated by inflammation-dependent changes in mucus, epithelial integrity, and immune-cell interactions. This critical narrative review examines comparative evidence from in vitro systems, animal models, and...

Surgical Ablation for Atrial Fibrillation During Minimally Invasive Mitral Valve Surgery: Risk Dependencies and Long-Term Survival

Objective: Atrial fibrillation (AF) is a common finding among patients with mitral valve disease, with a growing body of evidence showing survival benefits associated with surgical ablation (SA). However, a lack of data persists regarding the safety and survival after SA concomit...

Cognitive Function and Telemedicine-based, Village Doctor-led Care for Atrial Fibrillation

BACKGROUND AND AIMS: Cognitive impairment is common among older patients with atrial fibrillation (AF). We aimed to evaluate whether baseline cognitive function modifies the effectiveness of a telemedicine-based, village doctor-led integrated care in older patients with AF. METHO...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Recommendations of Multiple Sclerosis and Neuroimmunology Section of the Polish Neurological Society and the Polish Society of Gynecologists and Obstetricians for family planning and pregnancy management in women with multiple sclerosis: an update

INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the Central Nervous System that most commonly affects females of reproductive age. Therefore, the issue of family planning is relevant in this population, especially in the context of starting a...

Radium - from discovery to the present day – narrative review

Following its discovery, radium was initially promoted as a therapeutic agent for a wide range of conditions, including skin disorders, allergies, visual problems, joint pain, and as a general health-enhancing remedy. However, subsequent research demonstrated its significant radi...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...