Medical Research Network

Targeted DNA Sequencing Reveals Distinct Rare-Variant Profiles in Pulmonary Hypertension Associated with Chronic Lung Diseases

The mechanisms underlying the development and severity of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) remain poorly understood. To investigate the contribution of genetic factors, we performed targeted sequencing...

DisMed-LLM: De-Identifying Spanish Medical Text with Large Language Models

Abstract Patient privacy and compliance with regulations such as the General Data Protection Regulation (GDPR) necessitate the robust de-identification of clinical texts. This study investigates the feasibility, computational cost, and limitations of de-identifying Spanish medica...

Integrating genetics in the clinical care of patients with fibrotic interstitial lung diseases helps in diagnosis and predicting progression

Growing evidence suggests genetic basis in familial and other types of fibrotic interstitial lung disease (ILD). Genetics may improve diagnostic accuracy and risk stratification. The objective was to evaluate the utility of integrating genetic data into ILD clinical practice. A r...

Mapping the evidence on interventions to reduce potentially inappropriate prescriptions in older adults: a scoping overview of 127 systematic reviews

Potentially inappropriate prescriptions (PIPs) are highly prevalent among older adults and associated with adverse outcomes, including hospitalisations and mortality. Numerous interventions have been evaluated and synthesised in reviews, but the review-level evidence remains hete...

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune in...

The geochronological landscape of Mozambique: absolute dates from archaeological and palaeoenvironmental contexts

This paper presents a systematic review of absolute dating data from Mozambique, drawing on a compiled database of 442 dates from 69 sites. The dataset spans archaeological and palaeoenvironmental contexts and encompasses dates ranging from the present day to close to a half a mi...

Transcription-protein dissociation reveals disrupted cellular stress pathways in the prefrontal cortex of depression and schizophrenia subjects

Abstract Major depressive disorder (MDD) and schizophrenia (SCZ) are severe psychiatric disorders, the molecular mechanisms of which remain incompletely understood. Increasing evidence implicates neuroinflammatory signaling, autophagy dysregulation, and unfolded protein response...