Medical Center Hospital

Association of dietary antioxidant patterns with heart failure risk in patients with hypertension

Hypertension is a major modifiable risk factor for heart failure (HF) and contributes substantially to the cardiovascular disease burden in China. Oxidative stress and redox imbalance have been implicated in the progression from hypertension to HF. The composite dietary antioxida...

Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response

To investigate the association between preoperative anxiety and opioid tolerance in patients undergoing primary hip arthroplasty, focusing on heterogeneity across opioid types and the mechanisms underlying this association, this retrospective cohort study identified 1763 such pat...

Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair

Cisplatin resistance is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened a U.S. Food and Drug Administration (FDA)-approved drug library and identified fingolimod, an immunomodulatory agent, as a potent inhibit...