Medanta The Medicity

Molecular HLA matching in kidney transplantation: the emerging role of eplet mismatch analysis

Introduction Kidney transplantation is the preferred treatment for end-stage kidney disease, but long-term graft survival remains limited by alloimmune injury, particularly donor-specific antibody-mediated rejection. This review evaluates molecular HLA matching as an approach to...

The politics of translation in African-language generative AI: opportunities and challenges for critical engagement, education and resistance

This article explores the opportunities and challenges of knowledge exchange in East Africa around the societal implications of generative AI. These technologies’ capacity to work with and in certain African indigenous languages is increasing rapidly and generative AI is quickly...

Multimodality imaging localization of a giant functional parathyroid adenoma in a young fitness trainer with delayed recognition of hypercalcemia: A case report

Giant parathyroid adenoma (GPA) is a rare cause of primary hyperparathyroidism (PHPT) whose symptoms overlap with normal training fatigue and dietary shifts that calcium testing gets delayed in active people. A 36-year-old male fitness trainer presented with 13 kg of unintentiona...

Treatment gap in epilepsy is predicted more by patient perceptions than disease burden: Population‐based study from rural India

Abstract Objective To identify predictors of primary and secondary epilepsy treatment gap (TGap) in a rural Indian community. Methods We conducted a community‐based door‐to‐door survey of 130 509 individuals in 96 villages in rural Gujarat, India. Active epilepsy was diagnosed by...

Real-world outcomes and immune-related adverse events with PD-1/ PD-L1 inhibitors in metastatic renal cell carcinoma: A prospective observational study

Objectives: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have changed the management of metastatic renal cell carcinoma (mRCC). Most pivotal trials come from high-income settings and include highly selected patients. Prospective real-world data from low- and...

Cerebrotendinous xanthomatosis: Imaging clues to an underdiagnosed disorder

Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder resulting from defective bile acid synthesis, causing soft tissue deposition of cholesterol and cholestanol. It manifests with a wide spectrum of neurological as well as non-neurological fea...