Medanta The Medicity

Molecular HLA matching in kidney transplantation: the emerging role of eplet mismatch analysis

Introduction Kidney transplantation is the preferred treatment for end-stage kidney disease, but long-term graft survival remains limited by alloimmune injury, particularly donor-specific antibody-mediated rejection. This review evaluates molecular HLA matching as an approach to...

Treatment gap in epilepsy is predicted more by patient perceptions than disease burden: Population‐based study from rural India

Abstract Objective To identify predictors of primary and secondary epilepsy treatment gap (TGap) in a rural Indian community. Methods We conducted a community‐based door‐to‐door survey of 130 509 individuals in 96 villages in rural Gujarat, India. Active epilepsy was diagnosed by...

Cerebrotendinous xanthomatosis: Imaging clues to an underdiagnosed disorder

Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder resulting from defective bile acid synthesis, causing soft tissue deposition of cholesterol and cholestanol. It manifests with a wide spectrum of neurological as well as non-neurological fea...

Validation of STARZ scoring in very low birth weight (VLBW) neonates in the United States

Abstract Background Acute kidney injury (AKI) is a significant complication in very low birth weight (VLBW) neonates, associated with increased morbidity, mortality, and prolonged hospitalization. Early identification of at-risk infants enables timely interventions. The STARZ sco...