McMaster University Medical Centre

Protocol for the isolation, enrichment, and culture of murine adipose progenitor cells

We present a protocol for isolating and culturing murine adipose progenitor cells (APCs) from adipose tissue. We describe steps for tissue dissection, unit-normalized enzymatic digestion, stromal vascular fraction (SVF) isolation, APC enrichment, and cell culture. We then detail...

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...

Antioxidant premedication reduces mitochondrial and nuclear DNA damage repair in interventional physicians performing X-ray-guided angiography procedures: a pilot clinical intervention study

Abstract Background To examine effects of naturally occurring antioxidants on DNA damage repair acute responses of ionizing radiation sustained by interventional physicians during angiography. Methods The study cohort included 20 interventional physicians (19 males, 1 female; mea...

The Forgotten Joint Score Shows High Correlation With Established Anterior Cruciate Ligament Reconstruction Patient‐Reported Outcome Measures While Capturing Joint Awareness and Functional Recovery: A Systematic Review

PURPOSE: To systematically review and analyze the existing literature on the use of the Forgotten Joint Score-12 (FJS-12) in patients undergoing anterior cruciate ligament reconstruction (ACLR), with the aim of evaluating its effectiveness as a complementary tool to traditional p...

Orthobiologic Injections Adjunctive to Cartilage‐Preserving Surgery May Improve Outcomes for Focal Knee Chondral Defects: A Systematic Review of Randomized Controlled Trials With Subgroup Meta‐analyses

Purpose To perform a systematic review evaluating the efficacy of orthobiologic injections as adjuncts to cartilage‐preserving surgery in improving clinical, radiographic, and histologic outcomes in adults with focal knee cartilage defects. Methods Four databases (PubMed, MEDLINE...

From ‘Responsible’ to ‘Sustainable’: A Contingent Analysis of Responsible Entrepreneurship and Product Innovation Performance in an Emerging Economy

ABSTRACT While debate on responsible entrepreneurial activities for sustainable development is burgeoning, studies examining whether small and medium‐sized firms (SMEs) can benefit from responsible entrepreneurship remain underexplored. In this study, we draw on stakeholder theor...

Cross-sectional evaluation of anthropometric measures vs MRI-measured visceral and hepatic fat in a Canadian cohort

Abstract Context Accurate assessment of excess body fat and its cardiometabolic risk is essential in clinical and epidemiologic research. Body mass index (BMI), although widely used, does not capture visceral or ectopic fat. Objective To evaluate how anthropometric measures—BMI,...

Diffusion tensor tractography of the corpus callosum in major depressive disorder: a case-control study

Major Depressive Disorder (MDD) is a common and disabling psychiatric disorder that has been associated with alterations in white-matter microstructure, including abnormalities of the corpus callosum. This study aimed to compare the brain tracts of the corpus callosum using diffu...

Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue

BACKGROUND: Essential hypertension, characterized by vascular dysfunction, remains a leading modifiable cause of death globally. Perivascular adipose tissue (PVAT), which normally reduces vasoconstriction, becomes contractile in hypertension due to increased reactive oxygen speci...

Congenital Tuberculosis in a 2-Week-Old Neonate With an Asymptomatic Mother

Congenital tuberculosis (TB) is a rare condition, and diagnosis is challenging due to its nonspecific clinical presentation and rarity. It has a very high case-fatality rate (estimated at 30%–50%). We report the case of a 2-week-old male neonate, born from an uncomplicated diamni...

Interrogating the Effects of Technologies of Pregnancy Surveillance on Queer, Trans and Nonbinary Midwifery Service‐Users

Queer, transgender and nonbinary (QTNB) people access midwifery services, yet little is known about their experiences of midwifery care. Our qualitative study used critical narrative inquiry to examine how QTNB midwifery service-users in Ontario, Canada, experience cisheteronorma...