McGill University and Génome Québec Innovation Centre

Electrokinetic active grooves for liposome capture, confinement, trajectory analysis, and controlled release

Abstract Extracellular vesicles (EVs) are attractive candidates for minimally invasive disease monitoring. EV diagnostic signals often reside in low-abundant subpopulations, motivating single-vesicle measurements that can report distributions rather than ensemble averages. In pra...

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. We studied 28,842 diabetes-free UK Bioban...

Biomimetic Hydrogels with Nucleus Pulposus-like Viscoelasticity and ECM Peptides for Discogenic Differentiation of Stem Cells

Abstract Intervertebral disc (IVD) degeneration is a leading cause of low back pain (LBP), primarily originating in the nucleus pulposus (NP). Regenerative strategies combining mesenchymal stem cells (MSCs) with biomaterials offer great potential for NP repair by replenishing cel...