Max Planck School Matter to Life

Everyday ethical attentiveness in stem cell-based model research

The ethics of human stem cell-based models, from organoids to embryo models, has concentrated on the moral status and biological properties of research objects while overlooking everyday laboratory practices that shape and express ethical attitudes toward these objects before any...

Cell-derived lactate triggers local hydrogelation and phenotype remodelling

Abstract Many tumours release lactate as a major metabolic product and signalling molecule. Here we use lactate flux as an endogenous trigger for covalent hydrogel formation. Phenol-functionalised alginate remains soluble until cell-derived lactate is oxidised by lactate oxidase;...