Max Planck Institute of Molecular Cell Biology and Genetics

Mastodon: the command center for large-scale lineage-tracing microscopy datasets

Understanding development in living organisms requires following the divisions, movements, and fates of cells. While advances in microscopy have enabled whole-embryo imaging at the cellular level, extracting and analyzing cell lineages from these massive datasets remains a signif...

A topological approach to the Cahn–Hilliard equation and hyperuniform fields

Hyperuniform structures are disordered, correlated systems in which density fluctuations are suppressed at large scales. Such a property generalizes the concept of order in patterns and is relevant across diverse physical systems. We present a numerical characterization of hyperu...

Liver organoids: modelling complexity in homeostasis and disease

Liver is a complex organ, capable of incredible regenerative capacity in the mammalian body. In addition to well‐known hepatocytes, liver is composed of a complex cell microenvironment, with each cell type contributing to homeostasis, regeneration and disease. Modelling of the li...

Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

Abstract Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when used on affinity probes broadens lifetime distributions, limiting its practical applicability. We create a modular platform for FL e...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Born to Condense: Polysomes Drive Co-Translational Condensation of Biomolecular Condensate Proteins

This repository contains all necessary raw data and processed data used to generate the figures in this study.