Max Planck Institute for Polymer Research

Deciphering Dynamic Self‐Healing for Crystallinity Control in β‐Ketoenamine‐Linked Covalent Organic Frameworks

ABSTRACT Covalent organic frameworks derived from triformylphloroglucinol (Tp‐COFs) represent a prominent branch of COFs due to their high potential in separation, energy storage, and optoelectronics. However, the development of Tp‐COFs is often hindered by limited crystallinity,...

Bioinspired Mechanosensitive Organic Artificial Neuron With Programmable Excitatory and Inhibitory Responses via Nonlinear Mechano‐Electrochemical Coupling

ABSTRACT Neuromorphic systems capable of directly interfacing with the physical world are essential for embodied intelligence, wearable bioelectronics, and adaptive human‐machine interaction. However, most artificial neurons process mechanical and chemical stimuli through externa...

ABAG-Rank: Improving Model Selection of AlphaFold Antibody–Antigen Complexes by Learning to Rank

MOTIVATION: AlphaFold has transformed structural biology with an unprecedented accuracy in modelling protein structures and their interactions with biomolecules, with AlphaFold3 (AF3) achieving state-of-the-art performance. However, AF3 and other methods often struggle to accurat...

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

ABSTRACT Communication between living and artificial cells represents a fundamental step toward constructing hybrid systems capable of cooperative behaviors. Here, we introduce an ATP‐mediated energy transduction mechanism that enables bidirectional communication between natural...

Functional mapping and engineering of the Sec translocon unlocked by a cell-free system

Abstract Almost all proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present a cell-free protein synthesis platform that inserts SecYEG...