Max Planck Institute for Biology

Building coiled coils with polar cores

Coiled coils are formed by α-helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs-into-holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the...

Machine-optimized parametric computer assisted design (CAD) of a stable flying wing UAV glider

Abstract Designing a statically stable flying-wing UAV glider is a highly nonlinear problem in which small geometric changes cause large shifts in stability and performance. While prior work has applied gradient-based and gradient-free methods to flying-wing aerodynamic optimizat...

DVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in C. elegans

Telomeres are repetitive DNA sequences at the ends of linear chromosomes bound by specialized proteins. In our previous quantitative proteomics screen for telomere-binding proteins of Caenorhabditis elegans , we identified DVE-1, a homolog of mammalian SATB proteins and a transcr...