Marmara University

Intravesical tranexamic acid for gross hematuria in the emergency department: a prospective cohort study

Gross hematuria is a common emergency department(ED) presentation that is often managed with continuous bladder irrigation(CBI). Intravesical tranexamic acid (TXA) has been proposed as an adjunct, but supporting evidence is limited. We evaluated whether adding intravesical TXA to...

Modern endoscopic strategies for the diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma (CCA) presents considerable diagnostic and therapeutic challenges for the endoscopist. This review offers a focused and practical evaluation of contemporary endoscopic approaches for the diagnosis and management of CCA, with an emphasis on real-world applicabil...

Acquisition-parameter effects on image utility in near-infrared dorsal hand imaging: linking image signatures to repeatability and separability

Near-infrared dorsal hand imaging is often evaluated through downstream recognition, while acquisition settings are treated as fixed experimental details. This study examined whether controllable acquisition parameters alter objective image-derived signatures and protocol-level u...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

OBJECTIVE: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. METHOD: This c...

Nutritional Interventions During Pregnancy Improve Maternal and Neonatal Outcomes: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

INTRODUCTION: This systematic review and meta-analysis aimed to evaluate the effects of nutritional interventions during pregnancy on maternal and neonatal outcomes. METHODS: The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was...

DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma

Background/Objectives: Immune exclusion in head and neck squamous cell carcinoma (HNSCC) limits immunotherapy efficacy, yet the molecular determinants of stromal-immune organization remain incompletely characterized. The desmosomal cadherin DSG2 is highly expressed in squamous ep...

Medical Students’ Knowledge, Attitudes, and Behaviors Regarding Skin Cancer, Sun Exposure, and Vitamin D: An Evaluation for Curriculum Integration

Background: Skin cancer is among the most common preventable cancers worldwide, and adequate knowledge about sun exposure and Vitamin D is essential for early prevention. Medical students, as future physicians, should acquire appropriate knowledge and health-promoting behaviors d...

Effectiveness of Movement Representation Techniques in Chronic Non-Specific Spinal Pain: A Systematic Review and Meta-Analysis

Background and Objectives: Movement representation techniques (MRTs), including motor imagery and mirror therapy, have been investigated in several chronic pain conditions; however, their effectiveness in chronic non-specific spinal pain (CNSP) has not been specifically synthesiz...

Outcomes of living related kidney donors of recipients with familial mediterranean fever-associated Amyloid A Amyloidosis

BACKGROUND: Living kidney donation among carefully selected individuals is generally considered safe but post-donation health risks vary by factors including family history. Data on long-term outcomes of related living kidney donors of recipients with familial Mediterranean fever...

Clinical comparison of CAD/CAM nanohybrid composite and hybrid ceramic overlays in children with molar–incisor hypomineralisation: a split-mouth prospective randomized clinical trial

OBJECTIVES: This prospective, randomized, split-mouth clinical study aimed to compare the clinical performance and survival rates of CAD/CAM-fabricated nanohybrid composite overlays (NCOs) and hybrid ceramic overlays (HCOs) produced using a digital workflow in first permanent mol...

Can Artificial Intelligence Reliably Detect Risky Eating Narratives? A Comparative Analysis of YouTube Extreme Diet Videos

Aim: This descriptive study was conducted to identify characteristics that are related to binge eating in YouTube videos that have been shared with the keywords “extreme diet” and “diet challenge” and to compare classifications made by expert dietitians with those generated by an...

Improving Environmental Citizenship Competencies of Middle School Students Through Social Media-Supported Out-of-School Learning Methods: An Action Research Study

The main objective of this study is to improve the environmental citizenship competencies of sixth-grade students in social studies lessons using out-of-school learning environments and media tools. The study employed an action research method. The study group consisted of sixth-...

Incidence and risk factors of incisional hernia after CRS and HIPEC for colorectal-appendiceal peritoneal malignancies: a retrospective cohort study

Abstract Background Incisional hernia is a common late complication after extensive abdominal surgery and may significantly impair quality of life. The incidence and risk factors of incisional hernia in patients undergoing cytoreductive surgery (CRS) combined with hyperthermic in...