Markey Cancer Center

Associations Between Physical Activity Measurement Modality and Gut Microbiome in Breast Cancer Survivors

Background/Objectives: Physical activity (PA), physiological fitness, and the gut microbiome have each been linked to health outcomes among breast cancer survivors (BCS); however, these associations have been inconsistent. Few studies have directly compared the associations of se...

Delivery of Anticancer Gold-Dithiocarbamate via Thiolated Chitosan Nanoparticles

Abstract Thiolated chitosan nanoparticles (TCNs) are versatile biomaterials with applications in tissue engineering, coatings, wound healing, and drug delivery. Their biodegradability and ability to conjugate sulfhydryl-containing payloads make TCNs attractive as carriers for con...

Economic and health impact of integrating smoking cessation services into NHS cancer care pathways in England: a modelling study

Background Research has shown that smoking post-diagnosis negatively impacts cancer outcomes. This study aimed to assess the health and cost impacts of introducing smoking cessation services at cancer diagnosis for people who smoke. Methods A cost-effectiveness model was develope...

BRN2 in Lineage Plasticity: A Prostate Cancer-Focused Perspective

Lineage plasticity is a major mechanism by which prostate cancer adapts to therapeutic pressure, particularly following sustained inhibition of androgen receptor signaling. A central mediator of this process is BRN2, a POU3F2 neural lineage transcription factor that is normally s...

Trust in Cancer Information Sources During and After the COVID-19 Pandemic

This cross-sectional study explores changes in the level of trust in professional, governmental, and personal sources of cancer information among adults who participated in the 2018 to 2024 Health Information National Trends Survey.

Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation

Significance: Cerebral autoregulation (CA) reflects the dynamic coupling among cerebral blood flow (CBF), intracranial pressure (ICP), and arterial blood pressure (ABP); its failure contributes to secondary brain injury. Existing bedside methods rely on indirect or spatially limi...

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models

Phosphatase of regenerating liver 3 (PRL-3) is a cancer-associated protein linked to tumor progression, metastasis, and poor patient outcomes, but the mechanism underlying its oncogenic activity remains unresolved. PRL-3 functions both as a phosphatase and as a binding partner of...

Residential Context and Survival Disparities in Black and White Women With Ovarian Cancer

Importance: Black women with epithelial ovarian cancer (EOC) have significantly worse survival than White women. How residential context contributes to these disparities is unclear. Objective: To examine whether there is an association of residential context with racial dispariti...