March of Dimes

Bile acids and ursodeoxycholic acid alter gene expression in primary myometrial cells

Abstract Intrahepatic cholestasis of pregnancy (ICP), characterised by elevated maternal serum bile acids (BAs), increases risk of preterm labour that may be mitigated by ursodeoxycholic acid (UDCA) treatment. How different BA species, including UDCA, affect myometrial function r...