Manubhai Patel Dental College and Hospital

Box–Behnken design–based optimization of Imatinib mesylate PLGA nanoparticle-loaded gel for topical management of Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma Protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma. Its development is related to the specific PDGFB-COL1A1 fusion gene, which leads to constitutive signaling through tyrosine kinase. While Imatinib Mesylate is known to be effective in targetin...