Mansoura University Hospital

Nociceptin/Orphanin FQ Peptide (NOP) Receptor Agonists as Novel Analgesics in Pain Medicine

Chronic pain is a major cause of disability worldwide, impacting around 20% of adults globally. Conventional mu-opioid peptide (MOP) receptor agonists provide effective analgesia; however, their prolonged use is restricted by severe dose-limiting toxicities such as opioid-induced...

Sex Differences in Presentation, Management, and Prognosis of Surgically Treated Oral Tongue Carcinoma: A Retrospective Cohort Study

AIM: Tongue carcinoma is an aggressive subtype of oral cavity cancer. Sex-related differences in disease presentation and prognosis remain incompletely understood.METHODS: This retrospective cohort study included patients with histologically confirmed oral tongue squamous cell ca...

Increasing Detection of Early-Onset Rectal Neuroendocrine Neoplasms in the Era of Earlier Colorectal Cancer Screening

Background This study aimed to evaluate contemporary national trends in the presentation, management, and outcomes of early-onset rectal neuroendocrine neoplasms (EORNETs). Methods A retrospective cohort analysis of patients <50 years who underwent surgery for rectal neuroendocri...

Early-Onset Colorectal Cancer: Contemporary Management, Immunotherapy, and Organ Preservation

A 36-year-old man with no family history of colorectal cancer or inflammatory bowel disease presented with a 3-month history of bright red blood per rectum and constipation. Anoscopy demonstrated Grade II internal hemorrhoids, and he was initially treated conservatively with fibe...

Structural and Functional Cardiac Reverse Remodeling After Bariatric Surgery: A Prospective Comparison of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass

OBJECTIVE: Obesity is associated with characteristic cardiac remodeling, including left ventricular (LV) hypertrophy, concentric geometry, and subclinical myocardial dysfunction. Bariatric surgery induces reverse cardiac remodeling; however, it remains unclear whether structural...

Efficacy of direct oral anticoagulants in the prophylaxis of catheter-related thrombosis: The DOACAT study

Background and aim: Catheter-associated thrombosis is a frequent cause of tunneled catheter dysfunction, and evidence for prophylactic anticoagulation with direct oral anticoagulants is limited. This study evaluated the efficacy and safety of apixaban and rivaroxaban in preventin...

Role of choroid plexus cauterization in augmenting the success rate of endoscopic third ventriculostomy in Chiari II-associated hydrocephalus

OBJECTIVE: This study evaluates the efficacy and outcomes of endoscopic third ventriculostomy combined with choroid plexus cauterization (ETV + CPC) as a primary treatment for hydrocephalus associated with Chiari II malformation in infants. METHODS: This retrospective study analy...