Manipal College of Medical Sciences

Risk-stratified versus standard-duration dual antiplatelet therapy after percutaneous coronary intervention: a systematic review and critical appraisal of prospective evidence

Guidelines endorse risk-stratification tools (DAPT score, PRECISE-DAPT, ARC-HBR) to individualise dual antiplatelet therapy(DAPT) duration after PCI, yet a fixed 12-month course still imposes a uniform ischaemic-bleeding trade-off on a heterogeneous population. To our knowledge,...

Knowledge and Practices of Biomedical Waste Management Among Health Professionals and Waste Handlers in Hospitals of Kaski Districts of Nepal

BACKGROUND: Biomedical waste management (BWM) is an essential element of health safety and environmental protection. Government of Nepal introduced the Health care waste management guideline-2014; however, its implementation remains inconsistent. OBJECTIVE: To assess knowledge of...

Wild honey (grayanotoxin) intoxication and its complex interaction with pre-existing co-morbidities, influencing presentation and outcome: a case series

Background Grayanotoxin-containing wild honey causes cholinomimetic activity through voltage-gated sodium channel activation and increases the excitability of cardiac and neuronal membranes, leading to cardiovascular and neuronal toxicity. Prior studies describe general-populatio...