Manchester University NHS Foundation Trust

A feasibility randomised controlled trial of culturally appropriate physical activity promotion strategies among older Chinese adults in the UK

Abstract Background Informed by an evidence review and qualitative interviews and guided by the Behaviour Change Wheel (BCW) and person-based approach (PBA), we developed the first culturally appropriate physical activity (PA) promotion strategies for older Chinese adults in the...

Targeted community screening in areas of high socioeconomic deprivation enhances the detection of liver fibrosis.

BACKGROUND: Risk-factor-based community screening has been used to identify early liver disease. Risk-factor prevalence and liver-related outcomes are significantly affected by socioeconomic deprivation. However, the impact on targeted community screening is unknown. We evaluated...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

ACTIVATE: A protocol for a randomised controlled evaluation of Thumos: A cognitive-behavioural intervention for medical students

Background Medical students experience high rates of burnout and mental health distress, with approximately half reporting burnout, one-third experiencing depression, and one-tenth having suicidal thoughts. These issues are exacerbated during clinical placements and contribute to...

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who presented with axonal neuropathy, and assess functional consequences in vitro. Method In this retrospective, multicentre, observational study, we identified 10 individuals from s...

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Direct transfer to primary percutaneous coronary intervention centres following out-of-hospital cardiac arrest: longer term outcomes and influences on survival

Objective Myocardial infarction is a leading cause of out-of-hospital cardiac arrest (OHCA). In patients with OHCA due to suspected acute coronary occlusion, direct transfer to a centre capable of primary percutaneous coronary intervention (PPCI) has been shown to improve short-t...

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

Abstract Introduction The literature provides limited evidence on the effectiveness of psychological interventions for individuals living with Huntington’s Disease (HD). This study aims to examine the role of psychological support in improving the well-being of individuals and fa...

Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications

PURPOSE OF REVIEW: This review examines the mechanistic, epidemiological and therapeutic evidence underpinning liver integration into the cardiovascular-kidney-metabolic (CKM) construct. For the purposes of this review, we use the term cardiovascular-renal-hepatic-metabolic (CRHM...

Attendance Among People With Hepatitis B in UK Secondary Care: A Scoping Review.

Chronic Hepatitis B disease requires lifelong monitoring to prevent complications such as cirrhosis and hepatocellular carcinoma. Despite structured care pathways, non-attendance within UK secondary care remains challenging. This scoping review aimed to synthesise existing eviden...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...

Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain after Bariatric Surgery: A Longitudinal Study in a UK Public Healthcare Setting

OBJECTIVE: Bariatric surgery is an effective treatment for obesity. This study aims to identify demographic factors of weight loss and recurrent weight gain over a 10-year follow-up period. METHODS: This retrospective observational study includes 2092 patients for overall trends,...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Adaptive optics imaging in bilateral vitelliform maculopathy

This report presents the clinical, electrophysiological and multimodal imaging findings of an individual with bilateral vitelliform maculopathy. Adaptive optics imaging enables in vivo visualisation of retinal microstructure at cellular resolution, providing a detailed baseline f...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Mantle Cell Lymphoma With Major Salivary Gland Involvement Mimicking IgG4 ‐Related Disease/Mikulicz Disease—A Case Report

ABSTRACT Background Mantle cell lymphoma (MCL) is an uncommon subtype of non‐Hodgkin lymphoma with distinct clinical, biological, and molecular features, most commonly affecting older males. Extranodal involvement is frequent, although salivary gland presentation is rare. We repo...

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐ MAPS ) secondary to pelvic mesh devices for stress urinary incontinence ( SUI )

OBJECTIVE: The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non-surgical pathways of isolated mesh associated pain syndrome (I-MAPS) following insertion of a single continence tape. METHODS: Women with a single continen...

Fertility-Sparing Management of Atypical Hyperplasia and Endometrial Cancer from the Perspective of Molecular and Hormonal Profiles: A Meta-Analysis-Driven Framework

Background/Objectives: The prognostic and predictive values of biomarkers in fertility-sparing management of atypical hyperplasia (AH) and endometrial cancer (EC) remain ill-defined. We aimed to identify the impact of tumour profiles on oncologic and reproductive outcomes to info...