Manchester University NHS Foundation Trust

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Adaptive optics imaging in bilateral vitelliform maculopathy

This report presents the clinical, electrophysiological and multimodal imaging findings of an individual with bilateral vitelliform maculopathy. Adaptive optics imaging enables in vivo visualisation of retinal microstructure at cellular resolution, providing a detailed baseline f...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Mantle Cell Lymphoma With Major Salivary Gland Involvement Mimicking IgG4 ‐Related Disease/Mikulicz Disease—A Case Report

ABSTRACT Background Mantle cell lymphoma (MCL) is an uncommon subtype of non‐Hodgkin lymphoma with distinct clinical, biological, and molecular features, most commonly affecting older males. Extranodal involvement is frequent, although salivary gland presentation is rare. We repo...

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐ MAPS ) secondary to pelvic mesh devices for stress urinary incontinence ( SUI )

OBJECTIVE: The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non-surgical pathways of isolated mesh associated pain syndrome (I-MAPS) following insertion of a single continence tape. METHODS: Women with a single continen...

Fertility-Sparing Management of Atypical Hyperplasia and Endometrial Cancer from the Perspective of Molecular and Hormonal Profiles: A Meta-Analysis-Driven Framework

Background/Objectives: The prognostic and predictive values of biomarkers in fertility-sparing management of atypical hyperplasia (AH) and endometrial cancer (EC) remain ill-defined. We aimed to identify the impact of tumour profiles on oncologic and reproductive outcomes to info...