Manchester Academic Health Science Centre

A feasibility randomised controlled trial of culturally appropriate physical activity promotion strategies among older Chinese adults in the UK

Abstract Background Informed by an evidence review and qualitative interviews and guided by the Behaviour Change Wheel (BCW) and person-based approach (PBA), we developed the first culturally appropriate physical activity (PA) promotion strategies for older Chinese adults in the...

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study

Background Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1-expressing tissues, posing substantial...

In vitro and in vivo functional roles of three region 1 promoters in Escherichia coli K1 capsule gene cluster

Capsular polysaccharides are key virulence determinants in extraintestinal pathogenic Escherichia coli , protecting bacteria from host immune defences while modulating interactions with host tissues. In group 2 capsule gene clusters, transcription of region 1 genes required for c...

Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection

Many helminth parasites migrate through multiple host organs during infection, but how immune responses are relayed across these tissues is still poorly understood. To investigate the immune aspects of intertissue communication during infection, we established a percutaneous infe...

Targeted community screening in areas of high socioeconomic deprivation enhances the detection of liver fibrosis.

BACKGROUND: Risk-factor-based community screening has been used to identify early liver disease. Risk-factor prevalence and liver-related outcomes are significantly affected by socioeconomic deprivation. However, the impact on targeted community screening is unknown. We evaluated...

The effects of increasing and decreasing dopamine on inhibition of return: a psychopharmacological investigation

Abstract Inhibition of Return (IOR) is the phenomenon of being slower to re-attend to previously attended locations, and is thought to improve the efficiency of attention. Previous studies of dopaminergic disorders indicate that excessive or insufficient dopamine signaling in the...

Conserved circadian membrane rhythms arise from divergent cellular mechanisms in pacemaker neurons of mice and Drosophila

Abstract Circadian clocks align physiology and behaviour with daily environmental cycles, requiring neuronal networks that encode and transmit time-of-day information. Whether conserved electrophysiological principles underlie circadian output across evolution remains unclear. We...

The Great Leap: explaining the steepest part of the socio-spatial gradient in life expectancy in England

Background Socio-spatial health inequalities are increasing in England, as in many other high-income countries. While most research focuses on inequalities between the extreme ends of the deprivation continuum, a less recognised but critical pattern is that the largest gap within...

Economic and health impact of integrating smoking cessation services into NHS cancer care pathways in England: a modelling study

Background Research has shown that smoking post-diagnosis negatively impacts cancer outcomes. This study aimed to assess the health and cost impacts of introducing smoking cessation services at cancer diagnosis for people who smoke. Methods A cost-effectiveness model was develope...

Effects of a three-month exercise programme on cognition, mood and neurogenesis: the NeuroFit randomised controlled trial

Abstract Middle age represents a critical window for mental and cognitive change, yet it remains relatively understudied as a target period for preventative lifestyle interventions. We conducted a three-month randomised controlled trial in healthy middle-aged adults in the UK ( n...

EXPRESS: caADAMTS13 reduces neutrophil-mediated vascular inflammation without exacerbating bleeding in experimental intracerebral haemorrhage

Targeting thromboinflammation through the von Willebrand factor (VWF)/ADAMTS13 axis is a promising therapeutic target for acute ischaemic stroke (AIS). Constitutively active ADAMTS13 (caADAMTS13) is a novel thrombolytic that improves outcomes in experimental AIS, with enhanced th...

How is ‘culture’ made relevant in consultations between General Practitioners and ethnic minority patients?: a conversation analysis

Abstract Background General Practitioners (GPs)—usually the first points of healthcare in the UK—are required to provide ‘whole person care,’ by considering patients’ cultural backgrounds. Previous research suggests that doctors’ interactional behaviour can contribute to ethnic h...

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

Understanding and applying psychological formulation in secure children's homes: Insights from residential staff

Abstract Objectives Psychological formulation helps to develop an understanding of an individual's experiences and how they make sense of these. There is limited research around staff's perspectives of psychological formulation within the Children and Young People Secure Estate (...

Walking on the Number Line: A Playful and Embodied Group Intervention for People with Acquired Number Deficits (Acalculia)

Numbers skills are affected in as many as 65% of cases following a stroke or abrain-injury, a condition termed ‘acalculia’. Research into re-education ofmathematical skills has focused on using intense repetitions (‘drill’). Whileeducational theory has progressed, offering more e...

Attendance Among People With Hepatitis B in UK Secondary Care: A Scoping Review.

Chronic Hepatitis B disease requires lifelong monitoring to prevent complications such as cirrhosis and hepatocellular carcinoma. Despite structured care pathways, non-attendance within UK secondary care remains challenging. This scoping review aimed to synthesise existing eviden...

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time poi...

Efficacy of mRNA-based HPV Vaccines in Inducing Immune Response and Preventing Oncogenic Outcomes: A systematic review and meta-analysis

Background Human papillomavirus (HPV) infection represents a substantial global health burden, being the primary etiological agent of cervical cancer, anogenital and oropharyngeal malignancies. Although prophylactic virus-like particle (VLP) vaccines have been successfully implem...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Adaptive optics imaging in bilateral vitelliform maculopathy

This report presents the clinical, electrophysiological and multimodal imaging findings of an individual with bilateral vitelliform maculopathy. Adaptive optics imaging enables in vivo visualisation of retinal microstructure at cellular resolution, providing a detailed baseline f...