Manchester Academic Health Science Centre

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Adaptive optics imaging in bilateral vitelliform maculopathy

This report presents the clinical, electrophysiological and multimodal imaging findings of an individual with bilateral vitelliform maculopathy. Adaptive optics imaging enables in vivo visualisation of retinal microstructure at cellular resolution, providing a detailed baseline f...

Modelling Tetralogy of Fallot: insights and limitations of animal models

Tetralogy of Fallot (TOF) is the commonest cyanotic congenital heart disease, arising from antero-cephalad deviation of the outlet septum during outflow tract (OFT) morphogenesis, producing a ventricular septal defect, overriding aorta, pulmonary stenosis, and right ventricular h...

Use, trustworthiness and willingness to self-monitor health and personal wellness: a UK population survey

Abstract Background Public opinion about self-monitoring of health and personal wellness is important but largely unknown. This study investigated public attitudes towards self-monitoring of health and personal wellness. Methods Four thousand two hundred seventy UK adults selecte...

The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS), the most common type of motor neurone disease (MND), is a devastating diagnosis that often leads to mortality within 2–5 years of symptom onset. Respiratory failure and aspiration pneumonia both associated with respiratory muscle w...

Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD

BACKGROUND: The right-temporal variant of frontotemporal dementia (FTD) is well characterised. Whether it should be considered a distinct clinical entity, separate from other syndromes of FTD, remains an open question. The study addressed the issue through a retrospective compari...

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐ MAPS ) secondary to pelvic mesh devices for stress urinary incontinence ( SUI )

OBJECTIVE: The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non-surgical pathways of isolated mesh associated pain syndrome (I-MAPS) following insertion of a single continence tape. METHODS: Women with a single continen...

Development of a proposed guide to identify, screen and appraise self-report and device-based measures of habitual physical activity in systematic reviews: a methodological protocol

Habitual physical activity (PA) is a fundamental determinant of health, yet its assessment and reporting vary substantially across research studies, creating persistent challenges for evidence synthesis. Systematic reviews that aim to synthesise habitual PA outcomes are frequentl...

Priorities for breast cancer risk assessment in UK women under age 50: a survey and discrete choice experiment

BACKGROUND: National guidelines recommend English women between 30 and 49 years with moderate/high risk of breast cancer (BC) be offered screening and prevention interventions. Identification largely relies on family history-based criteria amongst women self-presenting in primary...

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Therapeutic needs to modulate brain circuits highlight graphene-based materials (GBMs) as an emerging tool to engineer specific interventions to treat neuro-diseases. In this context, graphene oxide (GO) nanosheets offer new drug delivery strategies to reach neural cells and sign...