Malaghan Institute of Medical Research

Nanoparticle accumulation in the lymph node is impaired in aged mice

Abstract Vaccine responses are impaired in aged mice and older people. A key first step in mounting successful responses to vaccines is for antigens to access the draining lymph node from the site of injection. Here we tested the hypothesis that nanoparticle drainage to the lymph...

Engineering antigenic breadth against SARS-CoV-2 by pairing divergent RBDs within a single mRNA immunogen

Abstract Vaccines capable of eliciting broadly neutralising antibodies (bnAbs) are a major goal for pandemic preparedness. A persistent challenge across vaccine Wields is how to deliberately recruit the rare B cell clones that recognise conserved epitopes shared across diverse vi...