Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Environmental and demographic determinants of Aedes albopictus seasonal activity in southern France: A modeling study

The presence and the activity of Aedes albopictus are a growing concern for nuisance and public health in Europe. Despite an increasing number of entomological and modelling studies, our incomplete understanding of mosquito population response to weather drivers in natural condit...

Complex non-falciparum transmission and widespread insecticide resistance sustain hyperendemic malaria in Penka-Michel, a focus of the Cameroon highlands

A 12-month longitudinal entomological study (September 2023-August 2024) in the Western Highlands of Cameroon (Penka-Michel) investigated malaria transmission dynamics and insecticide resistance markers, including target-site resistance (L1014F, N1575Y, G119S- Ace1 ) and metaboli...

Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants and for different types of vaccine platforms. We assessed anti-spike (anti-S) antibody binding to nin...

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will p...

ViroSeek: a viral detection pipeline for second-generation sequencing

Abstract Arbovirus emergences represent a rising public health issue and are exacerbated by climate change and globalization. Virome analysis has become a key approach for monitoring and managing infectious diseases, yet existing tools often remain technically complex and inacces...

Forgotten reservoirs: an attempt to revive field research on rodent malaria parasites in their main natural host, the thicket rat Grammomys poensis (formerly Thamnomys rutilans)

<title>Abstract</title> Rodent malaria parasites have long served as essential experimental models for understanding human malaria, yet little is known about their ecology and evolution in the wild. The thicket rat <italic>Grammomys poensis</italic> (formerly <italic>Thamnomys ru...

Prevalence and phenotypic profiles of ESBL-producing Escherichia coli across the human-animal-environment interface: a One-Health surveillance during the first year of implementation of the Tricycle project in Burkina Faso

Antimicrobial resistance (AMR) is a major global health threat. The WHO Tricycle protocol applies a “One Health” approach to monitor extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec) in humans, animals, and the environment. This study was aimed at presenting t...

Empirical evidence for a trade-off between reproduction and tumour dynamics in the freshwater cnidarian Hydra oligactis

Abstract Reproduction is a key life-history trait but often comes at the expense of somatic maintenance, including ageing and susceptibility to disease. While reproduction–immunity trade-offs have been experimentally demonstrated in the context of infectious diseases, whether rep...

SARS-COv-2, influenza and other respiratory virus co-circulation during an outbreak in a rural health zone in Democratic Republic of Congo, 2024–2025

Little is known about the global impact of co-circulation and co-infection of COVID-19 and influenza in Democratic Republic of the Congo (DRC). This study aims at analyzing data on SARS-CoV-2, influenza and other respiratory viruses collected during an outbreak response in the ru...