Maj Institute of Pharmacology

Post-weaning DHA or EPA supplementation attenuates depressive-like behavior and myelination deficits induced by maternal high-fat diet in rat offspring

Abstract Depression affects younger populations, while imbalanced diet may contribute to disease development, with myelin abnormalities representing one possible underlying mechanism. We previously showed that maternal high-fat diet (HFD; 60% energy from fat) during pregnancy and...

From amino acids to animal models: MAP2K2 mutations and their role in pathogenesis of CFC4 Syndrome

Abstract Background Cardio-facio-cutaneous syndrome type 4 (CFC4) is a rare RASopathy caused by germline mutations in the MAP2K2 gene, which encodes the MEK2 protein - a key kinase in the Ras/MAPK signaling pathway. Although the Ras/MAPK cascade has been widely studied due to its...

preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies

Abstract Pharmacogenetics (PGx) has traditionally focused on a small number of high-impact variants affecting drug response due to the fact that PGx studies are labor-intensive and therefore low-throughput. Population biobanks linked to electronic health records (EHRs), including...

Neutron elastic scattering at $$\varvec{30.8}$$ MeV on $$\varvec{^{\text {nat}}\textrm{Ce}}$$

Abstract Elastic scattering of fast neutrons at an incident energy of 30.8 MeV on a natural cerium target was measured during an experiment conducted at the Neutrons For Science facility at GANIL-SPIRAL2. This is the first measurement on cerium using incident neutron energy above...