Magna Graecia University

Structural determinants of communicable disease risk in asylum reception centres

Introduction With over 120 million people forcibly displaced globally, asylum reception systems represent critical epidemiological interfaces. This synthesis is not confined to a single geographic region: evidence was drawn from reception systems across high-income host countries...

Italian validation and exploratory measurement invariance of the food addiction symptom inventory (FASI)

Abstract Background The Food Addiction Symptom Inventory (FASI) is a clinician-administered semi-structured interview developed to assess addiction-like eating behaviors related to ultra-processed food consumption, but a validated Italian version is unavailable. This study aimed...

Implementation of IRRAflow active irrigation in neurosurgical patients: A case series and literature overview

Background Active fluid management systems such as IRRAflow aim to overcome the limitations of passive external drains by enabling simultaneous automated irrigation and aspiration in a closed circuit. In acute and chronic subdural hematoma (a/cSDH), it enables active subdural irr...

A Computational Workflow Integrating Explainable AI and Database Mining for the Prioritization of Antimicrobial Natural Products

The escalating threat of antimicrobial resistance demands the discovery of antibacterial agents with unprecedented chemical scaffolds. Natural products have historically been the most prolific source of antibiotics, yet the vast majority of catalogued natural products remain unte...

A Comprehensive Analysis of Extraction Methods, Phytochemical Characterization and Neuroprotective Potential of Curcumin

Curcumin, a natural polyphenol derived from Curcuma longa, exhibits multi-targeted anti-inflammatory, antioxidant, and neuroprotective activities. This review aims to evaluate its extraction methodologies, synthetic pathways, and neuroprotective potential across preclinical and c...

Folic Acid Supplementation Adherence During Pregnancy: Evidence from a Cross-Sectional Survey in Italy

Background/Objectives: Periconceptional folic acid (FA) supplementation is a cornerstone of primary prevention of neural tube defects (NTDs). However, adequate preconceptional FA intake remains suboptimal in Italy. This study aimed to assess FA use among pregnant women in the Cal...

Blood footwear impression depletion: comparative morphological and biochemical analysis of continuous and interrupted partial-drying transfer sequences

Abstract Blood-bearing footwear impressions represent an important source of information in Bloodstain Pattern Analysis (BPA), yet the dynamics of blood depletion during consecutive walking sequences remain poorly characterized. This proof-of-concept pilot study compared two bloo...

Dose- and Time-Dependent Effects of a Ferula communis Extract on Bone Remodelling in a Human Osteosarcoma Cell Line

Ferula communis is a herbaceous plant in the family Apiaceae and order Apiales. It has two chemotypes that cannot be distinguished botanically, although one is highly toxic while the other is not. The non-poisonous chemotype has many beneficial activities for human health, includ...

Weight Regain After Discontinuation of GLP-1 and GIP/GLP-1 Receptor Agonists: A Systematic Review

Background: Weight regain and loss of cardiometabolic benefit commonly follow the withdrawal of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonists, yet maintenance strategies are incompletely characte...

Impact of platelet-rich plasma (PRP) intra-articular injection on functioning and kinematic analysis in knee osteoarthritis patients: A prospective observational study

Purpose Osteoarthritis (OA) is a degenerative joint disease primarily affecting elderly, with the knee being the most involved joint. Platelet-Rich Plasma (PRP) therapy has shown promise in OA management. Our study aimed to descriptively characterize changes over time in performa...

Living with Carotid Artery Stenosis: A Qualitative Study on the Role of the Social Determinants of Health

Carotid artery stenosis (CAS) is a major cause of ischemic stroke, yet little is known about how social determinants of health (SDHs) shape patients’ experiences beyond biomedical risk factors. This qualitative study explored how individuals living with CAS perceive the influence...

The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence

Introduction: Berry-derived and berry-based interventions have gained increasing attention for their potential health benefits. Berries are rich in diverse bioactive compounds, including polyphenols and anthocyanins, which are associated with a broad range of biological activitie...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

Botulinum Toxin for Temporomandibular Disorder: Current Evidence, Clinical Applications, and Future Perspectives

Temporomandibular disorders (TMDs) are heterogeneous musculoskeletal conditions frequently characterized by pain, impaired mandibular function, and reduced quality of life. Botulinum neurotoxin type A (BoNT-A) has emerged as a potential therapeutic option, particularly for persis...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Managing Reward Systems Through HRM During Extreme Turbulence: Evidence From the Russia–Ukraine War

ABSTRACT Extreme turbulence forces organizations to reassess the strategic value of their human resource practices. This study examines how extreme turbulence, such as war, triggers changes in reward systems and explores how organizations respond, react and adapt to the contingen...

Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges

Cardiometabolic disorders arise from interconnected metabolic, inflammatory, oxidative, mitochondrial, and vascular abnormalities. Lichens produce structurally diverse secondary metabolites, including depsides, depsidones, dibenzofurans, anthraquinones, and other phenolic compoun...

Molecular Engineering of Aptamers for Glioblastoma Therapy: From Simple Antagonists to AI-Driven Approaches, a Narrative Review

Glioblastoma multiforme (GBM) is an extremely aggressive and lethal brain tumor, characterized by marked molecular heterogeneity, the persistence of glioma stem cells (GSCs), and the limited permeability of the blood–brain barrier (BBB), which collectively hinder therapeutic effi...