Magee-Womens Research Institute

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...

BLEND-M: cellular deconvolution with personalized DNA methylation references

Cellular deconvolution estimates cell type fractions in tissue samples, providing an in-silico alternative to costly and labor-intensive cell sorting techniques. Accurate fraction estimates are essential for DNA methylation (DNAm) analyses, as they enable adjustment for confoundi...

Residential Context and Survival Disparities in Black and White Women With Ovarian Cancer

Importance: Black women with epithelial ovarian cancer (EOC) have significantly worse survival than White women. How residential context contributes to these disparities is unclear. Objective: To examine whether there is an association of residential context with racial dispariti...