Madrid Health Service

Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progression and Resistance Through Supplement Therapy

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited treatment success and strong resistance to therapy. Natural killer (NK) cells are important immune cells that can destroy cancer cells, and their function can be improved through certain micronutr...

Lifestyle and its relationship with health literacy, sense of coherence and sociodemographic factors in a Spanish primary care population: a multicenter cross-sectional study

Health behaviors are driven by a complex interplay of individual and structural factors. While health literacy and sense of coherence are widely studied as psychosocial enablers of healthy lifestyles, evidence comparing their impact against broader social determinants of health r...

Association of blood-pressure time-in-therapeutic range with morbidity and mortality in hypertensive patients: a retrospective cohort study in the community setting

Abstract Background Hypertension is one of the leading modifiable risk factors for cardiovascular disease. This study assessed the association between good blood pressure control (GBPC), measured by time in therapeutic range (TTR) during the first year after hypertension diagnosi...

Faunal Deposits in Pre-Beaker Funerary Contexts at Humanejos (Parla, Madrid, Spain)

This study presents the first zooarchaeological analysis of the faunal remains associated with the pre-Beaker funerary contexts of Humanejos (Parla, Madrid, Spain). A total of 3974 animal remains recovered from 31 burial pits were analysed. Species representation was assessed usi...

Post-match biochemical signatures and their association with video tracking metrics in elite soccer (football) players using multiplatform targeted metabolomics

Abstract Urinary metabolomics offers promise for monitoring exercise‑induced physiological stress in football, yet evidence linking post‑match urinary markers to match workload in elite players remains limited. This study investigated pre‑ to post‑match changes in the urinary met...

Evolution of functional and mental status and quality of life in people aged 75 years and over after the COVID-19 pandemic in Spain: a prospective cohort study

The COVID-19 pandemic has had significant health and psychosocial consequences in the older adults. However, there is little community-based evidence that clearly distinguishes the effect attributable to SARS-CoV-2 infection to be differentiated from the contextual impact of the...