Mackay Junior College of Medicine, Nursing and Management

Multi-Locus Molecular Findings in Pediatric-Onset Inherited Metabolic Disorders: An Eight-Year Series of Outsourced Genomic Testing in Taiwan

Background/Objectives: Outsourced genomic testing can identify additional findings in patients with inherited metabolic disorders (IEMs), including lysosomal storage diseases. We examined these findings in a selected Taiwanese series. Methods: We retrospectively reviewed 13 patie...

Transthoracic Echocardiography-Assisted, Low-Fluoroscopy Left Bundle Branch Area Pacing: A Comparison of Implantation Approaches and Lead Types

Background: Transthoracic echocardiography (TTE)-assisted left bundle branch area pacing (LBBAP) is a potential supplementary to fluoroscopy-guided implantation and may reduce radiation. Objectives: To evaluate the feasibility and long-term stability of TTE-assisted, low-fluorosc...

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework

Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-pred...

EXPRESS: Effects of Aerobic, Resistance, and Combined Exercise on Inflammatory Markers in Patients with Metabolic Syndrome: A Systematic Review and Network Meta-Analysis

BACKGROUND: The comparative effectiveness of different exercise modalities on systemic inflammation in patients with metabolic syndrome (MetS) remains poorly defined. OBJECTIVE: To systematically evaluate and rank the effects of aerobic exercise (AE), resistance training (RT), an...

Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization

OBJECTIVES: Evidence on the effectiveness of antiviral therapy in preventing influenza-related severe illness and hospitalization among children remains limited. We hypothesized that early administration of antiviral therapy within 48 hours of symptom onset would significantly re...

Disproportionate Subgaleal Hemorrhage in an Infant: Abuse or Bleeding Disorder?

Subgaleal hemorrhage is uncommon in infants beyond the newborn period and, when disproportionate to the reported causal trauma, raises suspicion for child abuse. We describe a 9-month-old girl who developed a large right subgaleal and small epidural hematoma after a 50 cm fall. I...