LWL-Universitätsklinikum Bochum

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

Deep Brain Stimulation Modulates Nucleus Accumbens Theta-Band Power in a Rodent Model of Schizophrenia

Background/Objectives: Deep brain stimulation has proven a powerful treatment option for various neuropsychiatric diseases. In psychiatry, this is particularly relevant for schizophrenia, where up to one third of patients do not respond to current treatment options. To further un...

Analysis of brain volumetry and functional connectivity during resting state in patients with borderline personality disorder

Abstract Background Borderline Personality Disorder (BPD) involves affective instability, impaired emotion regulation, and self-injurious behavior, often linked to childhood adversity. Although prefrontal and insular abnormalities have been reported, the relationship between stru...

Empathy for pain processing in individuals with elevated internet addiction scores: an event-related potential study

Abstract This study aimed to comprehensively elucidate patterns of empathy impairment using self-report, performance-based, and electrophysiological measures, alongside two cognitive measures, in individuals with elevated internet addiction (IA) scores (HIA, n = 20) compared to t...

Measures for intersectional mental healthcare: results from a participatory interview and focus group study with psychosocial counsellors, people with experience of using mental health services and providers

BACKGROUND: Discriminatory practices and barriers to care are increasingly recognised as a significant challenge for mental healthcare institutions. Yet, little research has considered what measures people with experience of using mental health services and mental healthcare serv...

The impact of peer and media pressure on muscle dysmorphia for men and women in the general German population is mediated by the internalization of muscularity ideals

Abstract Background Muscle dysmorphia (MD) is characterized by an excessive concern of not being muscular enough. Sociocultural influences appear to play a central role in the internalization of muscular beauty ideals and the development of MD. No study has examined the potential...