Luzerner Kantonsspital

Referral pathways to pediatric rheumatology care in juvenile idiopathic arthritis: a multicenter study in France and Switzerland

Timely access to pediatric rheumatology (PR) care is critical for improving outcomes in juvenile idiopathic arthritis (JIA), yet, referral delays remain frequent. We aimed to examine the trajectories leading to PR care across two national healthcare settings. We conducted a multi...

Beyond Event-Free Survival: A Multi-State Analysis of Local Recurrence, Metastasis, and Death in Soft Tissue Sarcoma

Background/Objectives: Event-free survival (EFS) is widely used in soft tissue sarcoma (STS) research but combines clinically distinct outcomes such as local recurrence (LR), distant metastasis (DM), and death into a single endpoint. We aimed to decompose conventional EFS and cha...

Liquid Biopsy-Guided Surgical Decision-Making in Oligometastatic Non-Small Cell Lung Cancer: Toward Dynamic Risk Stratification in the Multidisciplinary Era

Oligometastatic non-small cell lung cancer (NSCLC) is defined anatomically by a threshold of five or fewer metastatic lesions across three or fewer organs. That definition is a proxy for a biological question it cannot answer: whether the metastatic process has been arrested at a...

Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

Background Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high‐sensitivity cardiac troponin (hs‐cTn). cMyC (cardiac myosin‐binding protein C), because of its fas...

Six-Fraction Ultra-Hypofractionated Radiotherapy for Tumours Adjacent to or Involving the Brachial Plexus: A Retrospective Cohort Study

Background/Objectives: Tumours abutting or involving the brachial plexus can cause pain and neurological deficits. We evaluated six-fraction ultra-hypofractionated radiotherapy with a simultaneous integrated boost (uhRT-SIB) in a predominantly palliative cohort. Methods: We retro...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Short‐ and Long‐Term Outcomes After Transcatheter Aortic Valve Implantation With Large Self‐Expanding Valves

BACKGROUND: Patients with large aortic annuli are a more challenging subgroup for transcatheter aortic valve implantation (TAVI), and data on long-term outcomes are sparse. AIMS: Compare outcomes of patients with large annular anatomies to outcomes of patients with regular anatom...

Oncogene-driven genomic profiles are linked to poor overall survival in muscle-invasive bladder cancer (MIBC)

Abstract Purpose Muscle-invasive bladder cancer (MIBC) is a genomically complex disease with limited biomarkers for predicting patient outcomes. This study aimed to identify molecular correlates of overall survival in MIBC through comprehensive genomic profiling. Methods Tumor DN...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

CT-based radiological score (AMESI CT-score) for severity of bowel injury in acute mesenteric ischemia

PURPOSE: To evaluate whether common bowel-related CT signs alone can reliably identify irreversible bowel injury in acute mesenteric ischemia (AMI) and to develop a radiological score to enhance reporting and assist clinical decision-making. METHODS: This ancillary analysis of th...