Lurie Children's Hospital

Characterizing In-Home Safety Challenges and Strategies for Children With Medical Complexity

OBJECTIVES: Medical advances have allowed more children with medical complexity (CMC) to live at home, but previous research has linked implanted tubes to patient safety events. We aimed to characterize challenges and strategies parents use to deliver their children's tube-relate...

Mean arterial pressure for children in US emergency department and prehospital settings

Objectives To externally validate previously reported centile curves for the mean arterial pressure (MAP) on paediatric acute care samples; derive centile curves for paediatric MAP in an acute care population and evaluate the association of age-adjusted MAP with prehospital and i...

Well-being, Learning Environment, and Mistreatment Among Unionized Versus Nonunionized Surgery Residents During the COVID-19 Pandemic

OBJECTIVE: To evaluate whether residency program unionization was associated with differences in resident well-being, learning environment, and mistreatment during the COVID-19 pandemic. BACKGROUND: Resident unionization increased following the COVID-19 pandemic, driven by concer...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Enablers of Sustainable Pediatric Epilepsy Surgery: A Qualitative Exploration of Global Neurosurgery.

BACKGROUND AND OBJECTIVES: Of 50 million people with epilepsy globally, up to 10 million with lesional drug resistance epilepsy may be able to achieve seizure control with surgical options. Although multidisciplinary surgical care for epilepsy is available in high-income countrie...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Reviewing RVUs: Relevant Billing Codes for Infectious Diseases Clinicians

Caitlin Naureckas Li, Joyce Cast, Sameer Patel, Taylor Heald-Sargent, Kathleen Murtagh, Ravi Jhaveri; Reviewing RVUs: Relevant Billing Codes for Infectious

Food for thought: a mixed methods analysis of nutrition decision making during bedside rounds in the neonatal intensive care unit

BACKGROUND: Variation in nutrition delivery contributes to poor growth in preterm infants in the neonatal intensive care unit (NICU); however, few studies have examined how clinicians develop nutrition plans. The aim of this research is to describe the nutrition decision-making p...

Nutritional Deficiencies, Complications, and Nutrition Therapy/Counseling in Pediatric Patients Using GLP-1 Receptor Agonists

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used to treat childhood obesity, prediabetes, and type 2 diabetes. We examined nutritional deficiency incidence and nutrition therapy/counseling (NT/C) utilization among pediatric GLP-1RA users. Met...

A Scoping Review of Psychological Distress Outcomes in NICU Healthcare Providers

The Neonatal Intensive Care Unit (NICU) is a demanding work environment that provides medical care for acutely ill and premature infants while supporting parents experiencing significant stress and psychological distress. This scoping review is the first to examine quantitative r...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

Mental Health Burden and Developmental Timing of Premature Ovarian Insufficiency in Adolescents and Young Adult Females: A Retrospective Cohort Study

POI and EOI are rare but impactful conditions among adolescents and young adults (AYAs). Little is known about the timing and incidence of mental health (MH) conditions among AYAs diagnosed with POI/EOI. Data were collected using MarketScan Medicaid administrative claims among fe...

Structural Heart Interventions in Women with Congenital Heart Disease

Abstract Purpose of Review To provide a review of current transcatheter interventions in women with congenital heart disease, with a focus on sex-specific considerations in diagnosis, management, and follow-up. Recent Findings As the field of pediatric cardiology advances and pat...

Development and Implementation of an Interactive Physician-Directed Nutrition Curriculum for Elementary School Students: Case Study from an Urban Public Elementary School

Background Childhood obesity remains a growing public health concern in the United States, however, opportunities for preventive nutrition education particularly during pediatric clinic visits are limited. Although elementary schools are an ideal setting for nutrition education,...

Accelerating AI in clinical care: policy priorities of the 2025 HHS request for information

A U.S. Department of Health and Human Services Request for Information seeks input on “Accelerating the Adoption and Use of Artificial Intelligence as Part of Clinical Care.” This solicitation could impact future policies on regulation, reimbursement, and research, with emphasis...

Examining Sex-Based Inequities in Pediatric Sports Medicine Research: A Systematic Review

BACKGROUND: Inequalities in the inclusion of male and female athletes have been documented in the sports medicine literature. However, the extent to which this phenomenon exists in studies of pediatric athletes remains poorly defined. The purpose of this study is to characterize...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

HeartMate 3 in Pediatric and Complex Populations: Physiologic Rationale, Patient Selection, and Management Strategies

The HeartMate 3 (HM3) left ventricular assist device (LVAD), initially designed for adults, is increasingly utilized in children, small adults, and those with congenital heart disease (CHD), necessitating expanded knowledge and collaborative efforts. This review highlights key ph...