Ludwig Cancer Research

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V61...

Quantitative in vivo flux analysis reveals tumor and host lipogenic remodeling in KRAS-driven lung cancer

Upregulation of de novo lipogenesis is a hallmark of aggressive cancers, underscoring its potential as a therapeutic target. However, metabolic studies of lipogenesis during tumorigenesis in vivo remain limited relative to molecular investigations. Here, we quantitatively examine...