Ludwig Cancer Research

Breast cancer stem cell metabolism: metabolic plasticity and microenvironmental regulation

Breast cancer stem cells (BCSCs) are a tumorigenic cell population implicated in tumor initiation, therapeutic resistance, metastasis, and disease recurrence. Increasing evidence indicates that metabolic reprogramming is a fundamental feature of BCSC biology, enabling these cells...

Dynamics, function, and regulation of mammary stem cells in development and disease

Understanding the heterogeneity of mammary epithelial cells and their contributions to postnatal development and regeneration is of great importance. Recent advances have defined the intrinsic complexity of the mammary epithelium, its stromal interactions, and the ontogeny of adu...