Longgang Central Hospital

FAM45A-Mediated Persistent Memory-Like Fibroblast Reprogramming Drives PM2.5-Exacerbated Allergic Asthma

Abstract Chronic coexposure to fine particulate matter (PM2.5) and house dust mite (HDM) allergen worsens allergic asthma outcomes, yet the stromal cell mechanisms linking combined environmental and allergic risk factors remain incompletely defined. Airway fibroblasts are traditi...

Multi-omics characterization of P2RX4-associated immune microenvironment features and proof-of-concept observations of peritumoral radiomic phenotypes in TNBC

Abstract Background Triple-negative breast cancer (TNBC) is characterized by a highly heterogeneous and immunosuppressive tumor microenvironment (TME). While the ATP-gated receptor P2RX4 is associated with inflammation, its cell-specific expression patterns, associations with TME...

Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation

ABSTRACT Postmenopausal osteoporosis (PMOP) is frequently complicated by iron accumulation, which exacerbates bone loss. Baicalein, a natural flavonoid with iron‐chelating and antioxidant properties, has shown bone‐protective effects, but its role in iron‐overloaded PMOP remains...

Sustaining teachers’ epistemic agency in AI-supported instructional design: An exploratory design-based study of a conversational-function approach

The increasing use of generative AI in instructional design raises concerns about cognitive outsourcing, as lesson planning may become overly shaped by algorithmic outputs. Because learning is situated and personalized, sustaining teachers' epistemic agency—responsibility for ins...

Longitudinal assessment of early childhood caries increment and exploratory dmft progression among children of medical college employees

Abstract Background This study aimed to evaluate the progression of early childhood caries (ECC) and identify its associated risk factors among preschool children of medical college employees. Methods From October 2021 to March 2023, baseline and two follow-up examinations were c...

Three-Dimensional NiCo2S4/MoS2 Heterostructured Nanoflakes on Nickel Foam as a High-Performance Electrocatalyst for Alkaline Hydrogen Evolution Reaction

Abstract The development of cost-effective, high-performance electrocatalysts for the alkaline hydrogen evolution reaction is imperative for sustainable hydrogen production via water electrolysis. However, the intrinsically sluggish reaction kinetics and insufficient exposed acti...

Timing of surgery for a melioidosis-associated abdominal aortic pseudoaneurysm: a case report

BACKGROUND: Melioidosis is a tropical infectious disease caused by Burkholderia pseudomallei. Although vascular involvement is rare, melioidosis-associated abdominal aortic pseudoaneurysm can rapidly progress and carries a high risk of rupture and mortality. Due to nonspecific ea...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

GSCA-UNet: a gated spatial-channel attention U-net for accurate skin lesion segmentation

Abstract Medical image segmentation is a fundamental component of computer-aided diagnosis, where automatic skin lesion segmentation serves as a critical upstream task by providing pixel-wise delineations for subsequent analysis. Deep encoder-decoder architectures, such as U-Net...

Three-year Comparative Efficacy and Safety of Repeated Low-level Red-light Therapy and Orthokeratology for Myopia Control in Children

Repeated low-level red-light therapy (RLRL) has emerged as a noninvasive intervention for myopia control in children. This study compared the 3-year efficacy and safety of RLRL and orthokeratology (OK). This retrospective study included 86 children treated with RLRL ( n = 40) or...

Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma

Background The prognostic relevance of inflammatory bowel disease (IBD)–colorectal cancer (CRC) shared host–microbe signatures in non-intestinal epithelial malignancies remains unclear. This study aimed to evaluate the prognostic and biological significance of an IBD-CRC shared h...

Construction and validation of a diagnostic model for interventricular septal hypertrophy based on electrocardiographic parameters and clinical factors

Interventricular septal hypertrophy (IVSH) is considered to be an early-stage alteration of left ventricular hypertrophy and is a major risk factor for a wide range of fatal arrhythmias and heart failure. We aimed to develop and validate a diagnostic model to detect patients with...

Identification of annexin A10 as a candidate serum biomarker associated with neurological outcome after cardiac arrest

Accurate early neurological prognostication following cardiac arrest remains a major clinical challenge because of post-resuscitation brain injury. Although biomarkers such as neuron-specific enolase (NSE) and neurofilament light chain (NfL) are widely investigated, limitations i...

Transverse Tibial Transport Accelerated of Diabetic Wound Healing via Enhanced Wnt/β-catenin-Driven BMSCs Mobilization and Angiogenesis

BACKGROUND: The management of severe diabetic foot ulcers (DFUs) remains a major clinical challenge. Tibial cortex transverse transport (TTT) has emerged as an effective surgical intervention, but its underlying mechanism, particularly concerning stem cell mobilization and signal...

Papillary urothelial neoplasm of low malignant potential: real-world diagnostic pitfalls and clinical outcomes from a case series

Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an uncommon non-muscle-invasive bladder tumor. Its indolent nature often leads to underestimation of diagnostic complexity and recurrence risk, particularly in real-world practice where pathological distinction...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

To explore the key influencing factors of the risk of nosocomial infection in patients with multiple myeloma (MM), to construct a prediction model to effectively assess the risk of infection, and to provide a basis for individualized infection prevention and control. 245 patients...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...