Longgang Central Hospital

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

To explore the key influencing factors of the risk of nosocomial infection in patients with multiple myeloma (MM), to construct a prediction model to effectively assess the risk of infection, and to provide a basis for individualized infection prevention and control. 245 patients...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...