London School of Hygiene & Tropical Medicine

Impact of Charlson Comorbidity Index conditions on one-year survival in patients with breast cancer: a Danish population-based cohort study

Breast cancer is the most frequently diagnosed malignancy in women. The Charlson Comorbidity Index (CCI) is a widely used tool for quantifying multimorbidity. As the population ages, breast cancer incidence and comorbidity prevalence are expected to grow. We therefore investigate...

Childcare in Transition: Evidence That Patterns of Childcare Differ by Degree of Market Integration in Northwestern Tanzania

Highlights This study uses novel data on multiple childcare types from both kin and nonkin in two culturally similar communities with varying market integration. It tests the hypothesis that market integration is associated with reduced kin support. Who provides support and the t...

Trends and patterns of varicella zoster virus infection in Kilifi: A population-based serosurvey

Abstract There is limited epidemiologic data on varicella zoster virus (VZV) infections from low- and middle-income countries including Kenya. We aimed to describe the seroepidemiology of VZV in Kilifi, Kenya, where varicella vaccine is not included in the national infant immuniz...

How much are households willing to invest in hand hygiene enabling technologies? A randomised pricing experiment in Lusaka, Zambia

Abstract Access to a dedicated handwashing facility (HWF) increases handwashing with soap (HWWS), an effective behaviour for preventing respiratory and diarrheal disease. Achieving universal hand hygiene will require household investment of a HWF, yet the ability and willingness...

Strengthening insecticide resistance management in malaria vectors control in Côte d’Ivoire: from evidence to action

Malaria remains a major public health challenge in Côte d’Ivoire, particularly among young children and pregnant women. Insecticide-treated nets (ITNs) have significantly reduced transmission, but their effectiveness is increasingly threatened by widespread insecticide resistance...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

Optimising Pharmacovigilance Efficiency with MLIT (Machine Learning for Intelligent Triage): A Tool for Statistical Safety Alerts

BACKGROUND AND AIM: Pharmacovigilance is essential to ensuring patient safety by enabling timely identification of adverse reactions in increasingly complex and voluminous data. Routine quantitative signal detection methods generate statistical alerts for product-event pairs base...

Insecticide resistance profile and efficacy of next-generation LLINs against pyrethroid-resistant Anopheles gambiae s.l. in M’bé, central Côte d’Ivoire

Long-lasting insecticidal nets (LLIN) combining pyrethroids with synergists or partner insecticides represent the next-generation tools for controlling malaria transmitted by resistant vectors. Because of their differing modes of action, their deployment in a given area would req...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...

Balancing cancer innovation with sustainable care

<i>Investment in innovative drugs must not come at the expense of wider cancer services</i>

Comparison of parametric versus machine-learning multiple imputation in clinical trials with missing continuous outcomes

Abstract Background Flexible machine-learning (ML) models to generate imputations within the Multiple Imputation (MI) framework has recently gained traction, particularly in non-randomised observational settings. For randomised controlled trials (RCTs), it is unclear whether ML a...

A model for the epidemiological impact of tuberculosis policy options.

Objective: To develop a new tuberculosis transmission model, addressing the limitations of and building on the TB Impact Model and Estimates software tool, to enable decision-makers to assess the impact of various tuberculosis interventions and allocate resources more effectively...

Which stage of pharmaceutical procurement is perceived to be most vulnerable to corruption in public tertiary hospitals in Enugu State, Nigeria?

Pharmaceutical procurement in public tertiary hospitals is a critical component of healthcare delivery but may be vulnerable to corruption because it involves large financial flows, complex technical decisions and multiple actors. In Nigeria, corruption in health sector hinders a...

How are local authorities responding to climate change and health impacts? a policy document analysis of four England regions

Abstract Background Climate change poses growing risks to population health. In England, local authorities can influence key determinants of climate-related health outcomes through responsibilities for housing, transport, environmental protection and public health. However, clima...