London Health Sciences Centre

Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

BACKGROUND: Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce. METHODS:...

IncobotulinumtoxinA for Upper Limb Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Trial

This double-blind, placebo-controlled, phase II trial (NCT04766723) investigated the efficacy and safety of incobotulinumtoxinA (Xeomin®) in the treatment of essential tremor (ET) of the upper limb (UL). Adults with ET of the UL were randomized 2:1 (n = 78) and treated (n = 77) w...

Three decades of sexual and reproductive health literacy and information behaviour research on adolescent and young adult males: a scoping review

The transition to adulthood for adolescent and young adult males, those aged 17 to 24, is often characterized by heightened sexual and reproductive health (SRH) risks. These risks are frequently attributed to rigid masculinity norms, insufficiently targeted health interventions,...

Resilience profiles of children previously exposed to parental gender-based violence: A longitudinal decision tree analysis

Background Children exposed to parental violence (CEPV) may experience a range of adverse outcomes compared to non-exposed peers yet may demonstrate resilience shaped by both internal and external protective factors. Objective To longitudinally explore the profiles of protective...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Ethical guidance for randomized controlled trials of donor interventions in deceased organ donation: a scoping review of international guidelines, consensus statements, and expert recommendations

Deceased donor interventions are nontherapeutic interventions to improve the likelihood of successful donation and transplant outcomes. Randomized controlled trials (RCTs) could strengthen the evidence base for donor interventions, but such trials face difficult ethical challenge...

Tibial migration of a novel cementless total knee arthroplasty

Aims The search for enhanced fixation and longevity in total knee arthroplasty (TKA) continues. Radiostereometric analysis (RSA) allows early detection of implant migration predictive of future aseptic loosening and is the recommended method for evaluating new implants. This mult...

From Awareness to Action: Co‐Designing Culturally Safe and Equitable Rehabilitation in Canada – Protocol for the Two‐Phase Ireach Qualitative Study

ABSTRACT Background Inequities in access, engagement, and outcomes persist across outpatient rehabilitation services in Canada, disproportionately affecting Indigenous Peoples, newcomers and refugees, gender‐ and sexually‐diverse individuals, and people with lower income. Althoug...

Cardiovascular–Cognitive Associations During Physiological Challenges in Relapsing-Remitting Multiple Sclerosis

Background: Cognitive impairment, particularly reduced information processing speed (IPS), is a clinically meaningful manifestation of multiple sclerosis (MS). The Symbol Digit Modalities Test (SDMT) is a sensitive, validated measure of IPS widely used in MS research. While vascu...

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

OBJECTIVE: We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. METHODS: We enrolled patients within 3 months of JIA diagnosis in th...

Presence of asymptomatic lesions in myelin oligodendrocyte glycoprotein antibody-associated disease and neuromyelitis optica spectrum disorder: a retrospective study

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) can present with asymptomatic lesions in the absence of corresponding clinical symptoms. These lesions may represent inter-attack subclinical disease activit...

Investigating the role of the hippocampus in the implicit and explicit expression of statistical learning in patients with temporal lobe epilepsy

Statistical learning (SL) has been proposed to depend on the hippocampus, but traditional neuropsychological theories of long-term memory posit that the hippocampus is only necessary for explicit memory processes, not implicit memory processes. To reconcile these two accounts, we...

Neuroligin 3 highlights the sexually dimorphic neural substrates of Drosophila social spacing

Abstract In Drosophila melanogaster, Neuroligin 3 (Nlg3) is a postsynaptic membrane protein important for synapse development and social spacing behaviour, and its human orthologs are associated with autism. We localized Nlg3 to three brain structures: the mushroom bodies (MB) ca...

Ethical and Methodological Features of Cluster Randomized Trials in Critical Care Settings: A Systematic Review

OBJECTIVES: Cluster randomized trials (CRTs) are useful for evaluating system-level interventions in critical care but raise complex ethical and methodological issues that are amplified in this setting. We aimed to describe ethical and methodological features of CRTs in critical...

Characterisation of the HLA‐DPA1*01:194:01:02 Allele by Next‐Generation Sequencing

Novel HLA-DPA1*01:194:01:02 allele identified in Canadian liver transplant candidate of European descent by next-generation sequencing.

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

Evaluating the performance of administrative data elements used to document homelessness among psychiatric patients in Ontario, Canada: a validation study

Housing information about patients admitted to hospitals is routinely documented in health administrative records, which are increasingly used to inform planning and research. This study aimed to evaluate the accuracy of these records in identifying people experiencing homelessne...