London Centre for Neglected Tropical Disease Research

Health, workforce, and cost trade-offs of HIV programme prioritization strategies in Malawi

Background: Malawi has achieved substantial progress towards HIV epidemic control, reaching the UNAIDS 95–95–95 targets. However, declining external financing and health-workforce constraints threaten sustainability. Programme reconfiguration is being considered to reduce resourc...

A reusable model of pangenome selection informs optimal surveillance strategies over vaccine introductions

Abstract Background The human pathogen Streptococcus pneumoniae is a major cause of disease, including pneumonia and meningitis. The introduction of Pneumococcal Conjugate Vaccines (PCVs) initially reduced the burden of disease through a reduction of colonisation by vaccine-targe...