London Cancer

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are widely used to image intracellular environments. Here we report donor–acceptor dyads based on the BODIPY chromophore in which PET is selectively activated upon hydration. Replacing fluorine groups at bo...

A qualitative exploration of information access and provision for cancer survivors experiencing chronic bowel symptoms after pelvic radiotherapy: informing a framework to guide improvements to information provision

Abstract Purpose For people living with and beyond cancer, access to clear, accurate, relevant information is crucial for meaningful participation in shared decision-making and is associated with better quality-of-life. Many cancer patients who undergo pelvic radiation experience...

Physical activity in advanced urological cancers undergoing immune checkpoint inhibitor treatment: a qualitative study exploring patient perspectives and experiences

Physical activity (PA) can improve health and treatment outcomes in cancer patients. However, patients with advanced cancer undergoing immune checkpoint inhibitor (ICI) therapy often experience debilitating side-effects that impact PA participation. Because PA experiences in pati...

EFAU-Net: efficient feature-enhanced U-Net for early pregnancy ultrasound segmentation

Early-pregnancy ultrasound images often contain gestational sac, yolk sac, and embryo regions with blurred boundaries, variable shapes, and small target sizes, which makes accurate segmentation difficult. In addition, many existing segmentation networks have high computational co...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy

Intrathecal delivery for central nervous system (CNS) therapy lacks spatiotemporal control due to spinal canal anatomical constraints, especially at human scale. We developed an adaptive magnetic nanorobotic platform enabling multimode swarm mobility for in vivo spinal canal navi...