Institution
Loewe Center for Synthetic Microbiology
Recent research
- BiologyOpen access
Abstract Synthetic biology and the emerging field of biomanufacturing provide new research concepts that should be incorporated into the training of the next generation of scientists. Key elements of synthetic biology are the standardisation, modularisation, and characterisation...
- BiologyOpen access
Drift, selection and recombination bias drive the evolution of a non-ribosomal peptide
Abstract Non-ribosomal peptides play important roles in microbial ecology and medicine, for example as toxins and antibiotics such as penicillin. Like ordinary proteins, non-ribosomal peptides are subject to evolutionary change, which is driven by rampant recombinations of their...
- Engineering & TechnologyOpen access
Recent phylogenomic analyses revealed that the genus Methanobrevibacter , which consists almost exclusively of representatives from the intestinal tract of animals, is severely underclassified. Based on the large relative evolutionary divergence between individual subclades, memb...
- BiologyOpen access
Functional mapping and engineering of the Sec translocon unlocked by a cell-free system
Abstract Almost all proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present a cell-free protein synthesis platform that inserts SecYEG...
- Health & MedicineOpen access
Abstract Seasonal influenza remains a leading cause of global morbidity and mortality, highlighting the need for vaccination strategies that improve coverage and streamline vaccine delivery. In this systematic review and meta-analysis, we searched PubMed, Embase, Web of Science,...