Local Government Improvement and Development

Civic ecosystem responses to compound crises: evidence from Syria

Abstract Compound crises have attracted growing interest from scholars and policymakers in recent years. Little attention, however, has been directed to the social relations that emerge from and respond to such phenomena. This paper closes the gap by investigating the emergence,...

Enantiomer-dependent biodistribution and exposure determine the in vivo behavior of a pleurocidin-derived antimicrobial peptide

ABSTRACT Antimicrobial peptides (AMPs) display rapid bactericidal activity in vitro , but have largely failed as systemically administered therapeutics, indicating that intrinsic potency alone does not predict in vivo efficacy. Here, we examine how pharmacokinetics, stereochemist...