Living Systems (United States)

A Novel Striated Membrane Contact Site in Vestibular Hair Cells

The mammalian vestibular system has two types of sensory receptor hair cells (HCs), each with different neurotransmission mechanisms. Type II HCs use ribbon synapses to transmit neurotransmitters like glutamate to bouton terminals of afferent neurons. Type I HCs are nearly engulf...

Prophage and metabolic determinants of Staphylococcus aureus survival to vancomycin identified via TraDIS screening

ABSTRACT Reduced vancomycin susceptibility phenotypes in Staphylococcus aureus contribute to treatment failure, yet the genetic determinants of survival under inhibitory vancomycin exposure remain incompletely defined. We performed transposon-directed insertion-site sequencing (T...

Two Providers, a Stubborn Plateau, and a Very Long Tail: Email in the Tranco Top 1M

This study examines ten years of changes in email infrastructure across the Tranco Top 1M using large-scale DNS measurements. It analyzes the evolution of self-hosted email, Google Workspace, Microsoft 365, the long tail of MX providers, and the adoption and enforcement character...

PERFORMANCE OF HIV DRUG RESISTANCE EARLY WARNING INDICATORS AND ASSOCIATED PROGRAM FACTORS IN LESOTHO DURING THE DOLUTEGRAVIR ERA

HIV drug resistance (HIVDR) remains a major threat to the long-term effectiveness of antiretroviral therapy (ART) programs, particularly in settings where routine resistance testing is limited. Although dolutegravir (DTG)-based regimens have improved treatment durability, program...