Liverpool School of Tropical Medicine

Evaluating mental health and psychosocial support outcomes of the Self-Efficacy and Knowledge (SEEK) community-based randomized controlled trial in lebanon during active conflict

<title>Abstract</title> <bold>Background:</bold> Adolescent girls and young women (AGYW) affected by forced displacement are at high risk of poorer mental health and psychosocial wellbeing due to intersecting stressors. In humanitarian contexts like Lebanon, mental health challen...

Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

Abstract Background Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk population...

Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial

Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

Does plastic waste present an infection hazard? Current evidence, surveillance challenges and research priorities

Abstract Unmanaged plastic waste is widespread in settings with limited waste collection, yet its contribution to infectious disease risk remains poorly understood. In this review, we synthesise current evidence on the human health implications of plastic waste, with a specific f...

Escalating pyrethroid resistance in Anopheles funestus increases Plasmodium transmission

<title>Abstract</title> <bold>Background:</bold> The swift rise in pyrethroid resistance among malaria vectors poses a significant challenge to global malaria control. Although vector control tools have advanced, limited understanding of the vectorial capacity of highly pyrethroi...

Insecticide resistance profile and efficacy of next-generation LLINs against pyrethroid-resistant Anopheles gambiae s.l. in M’bé, central Côte d’Ivoire

Long-lasting insecticidal nets (LLIN) combining pyrethroids with synergists or partner insecticides represent the next-generation tools for controlling malaria transmitted by resistant vectors. Because of their differing modes of action, their deployment in a given area would req...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Detection of Plasmodium falciparum-infected Anopheles sergentii with reduced insecticide net susceptibility in a dryland ecosystem of the Kenyan Rift Valley: implications for malaria surveillance and vector control

Abstract Background In Kenya, parts of the dryland ecosystems have disproportionately witnessed a surge in malaria burden amidst poor understanding of the entomologic risk factors. This study investigated whether this trend is linked to shifts in the vector landscape, including t...

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...