Liverpool Heart and Chest Hospital

Association of Long-Term Residentially Assigned Speciated Atmospheric Mercury Emission Flux with All-Cause and Cause-Specific Mortality

Abstract Mercury (Hg) is a persistent global pollutant, but population evidence on residentially assigned species-specific atmospheric Hg emission flux and mortality is limited. We analyzed UK Biobank cohorts for all-cause/other-cause (N = 322,666), cardiovascular disease (N = 34...

Prognostic Value of Coronary Computed Tomography Angiography–Derived Fractional Flow Reserve From a Large Nationwide Cohort

BACKGROUND: The diagnostic value of coronary computed tomography angiography–derived fractional flow reserve (FFR-CT) in stable coronary artery disease is well established. The prognostic value of predicting future cardiovascular events is less clear, as studies are limited by sm...

Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial

BACKGROUND: Nutrition therapy is essential in critically ill patients, yet large randomised trials have shown inconsistent results regarding the effect of an evidence-based feeding protocol. The NEED trial showed a feeding protocol could effectively promote delivery of enteral nu...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...

Cardiac Electro-structural Remodeling and Arrhythmia Risks Across the Spectrum of Obesity Defined by the New Lancet framework

Abstract Background Obesity is linked to higher arrhythmia risk, yet BMI overlooks its complexity. Recently, the Lancet Commission has introduced a new obesity framework. We aimed to compare arrhythmia risks across distinct obesity categories. Methods Participants from the UK Bio...

Handgrip strength and/or Timed Up and Go Test are associated with functional independence and psychological well-being in older women

Abstract Background Handgrip strength (HGS) and Timed Up and Go (TUG) tests are established measures of physical capacity and widely utilized in geriatric assessments. We aimed to assess their independent and combined association with activity of daily living (ADL) and psychologi...

Cognitive Function and Telemedicine-based, Village Doctor-led Care for Atrial Fibrillation

BACKGROUND AND AIMS: Cognitive impairment is common among older patients with atrial fibrillation (AF). We aimed to evaluate whether baseline cognitive function modifies the effectiveness of a telemedicine-based, village doctor-led integrated care in older patients with AF. METHO...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...