Liuzhou General Hospital

Identification of key signature genes and construction of a diagnostic model for heart failure based on integrative transcriptomic and eQTL-based analyses and single‑cell eQTL Mendelian randomization

Heart failure (HF) is a life-threatening end-stage syndrome of cardiovascular disease with a rapidly increasing global incidence. Its underlying biological mechanisms remain unclear, and current biomarkers lack sufficient diagnostic accuracy. Single-cell eQTLs and Mendelian rando...

A Predictive Enrichment Model for Auricular Acupoint Stimulation in Post-Stroke Shoulder-Hand Syndrome: Identifying Baseline Effect Modifiers

Background Auricular acupoint stimulation (AAS) improves upper limb function in poststroke shoulder–hand syndrome (SHS), but treatment response heterogeneity limits personalized application. We aimed to identify baseline effect modifiers that predict differential response to AAS...

CAR-based therapies in systemic autoimmunity: from deep immune depletion toward durable immune reset

Systemic autoimmune diseases are sustained by self-renewing networks of autoreactive B cells, antibody-secreting cells, pathogenic T-cell programs and tissue-resident inflammatory niches. Conventional immunosuppression and biologic therapy can reduce disease activity, but often f...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

Effects of robot-assisted gait training on walking capacity and gross motor function in children with central nervous system impairments: a systematic review and meta-analysis predominantly based on cerebral palsy studies

Abstract Background Children with cerebral palsy (CP) and other central nervous system (CNS) impairments often have limitations in walking capacity and gross motor function. Robot-assisted gait training (RAGT) is increasingly used in pediatric rehabilitation, but existing evidenc...

The PDE3-specific inhibitor milrinone improves asthenozoospermic sperm function by regulating cAMP–PKA signaling pathway and energy metabolism

CONTEXT: Inhibiting phosphodiesterase (PDE) activity to increase cyclic adenosine monophosphate (cAMP) concentrations is a core strategy in artificial sperm activation. PDE3, a key member of the PDE family, comprises two subtypes, PDE3A and PDE3B. However, their specific expressi...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...