Lishui City People's Hospital

State-Primed modulation: sequential enhancement of transcranial magnetic stimulation efficacy for psychiatric disorders

Transcranial magnetic stimulation (TMS) is a well-recognized effective treatment for various psychiatric disorders, but its efficacy is substantially influenced by the ongoing internal states of neural activity. This article is a narrative viewpoint and does not aim to provide a...

Monocyte-to-HDL cholesterol ratio and cardiovascular comorbidity in COPD

Chronic obstructive pulmonary disease (COPD) is frequently complicated by cardiovascular disease (CVD), which significantly increases morbidity and mortality. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a novel inflammatory biomarker associated...

Olink proteomics reveals immuno-inflammatory profile changes and potential regulatory mechanisms of non-suicidal self-injury behavior associated with depression in adolescent

Abstract Background N on- s uicidal s elf- i njury (NSSI) frequently co-occurs with adolescent depression. The underlying immunoinflammatory mechanisms and peripheral biomarkers remain poorly understood. This study aimed to identify plasma proteins associated with NSSI in depress...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Sex-specific differences in the relationship between prolactin and glucose metabolism in first-episode schizophrenia

Hyperprolactinemia and glucose dysregulation frequently co-occur in schizophrenia; however, their sex-specific interplay at illness onset remains poorly understood. We hypothesized that there was sex difference in abnormal glucose metabolism and prolactin (PRL) levels, as well as...

Transcriptome atlas of Phascolosoma esculenta tissues: analysis of tissue-specific functions and gametogenesis-related genes

Phascolosoma esculenta , a commercially and ecologically significant sipunculan worm, lacks comprehensive molecular data regarding its tissue-specific functions and reproductive mechanisms. In this study, we constructed the first multi-tissue transcriptome atlas of P. esculenta ,...

The RBMS1–SLC7A11 axis regulates ferroptosis susceptibility and lenvatinib sensitivity in hepatocellular carcinoma

Hepatocellular carcinoma remains a leading cause of cancer-related mortality worldwide. Although lenvatinib is widely deployed as a frontline systemic therapy for advanced disease, its clinical utility is frequently subverted by primary or adaptive non-responsiveness. Evasion of...

Association between neutrophil-to-HDL cholesterol ratio and diabetic nephropathy in adults with diabetes mellitus

Renal complications in diabetes impose substantial morbidity globally, yet early risk stratification remains challenging. The neutrophil-to-HDL cholesterol ratio (NHR) represents an integrated biomarker reflecting both immune activation and dyslipidemia, with neutrophilia promoti...

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

<title>Abstract</title> Abemaciclib is used for the treatment of breast cancer (BC) in clinics. The combination of abemaciclib and imperatorin or isoimperatorin has been studied <italic>in vitro</italic> and <italic>in vivo</italic> to explore the pharmacokinetics of Chinese herb...

The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

Background and Purpose Previous studies have highlighted the significance of the bile acid receptor TGR5 (also known as Takeda G protein‐coupled receptor 5) in regulating inflammation and mitochondrial homeostasis in various diseases, whereas the specific involvement of TGR5 in s...