Lishui City People's Hospital

Transcriptome atlas of Phascolosoma esculenta tissues: analysis of tissue-specific functions and gametogenesis-related genes

Phascolosoma esculenta , a commercially and ecologically significant sipunculan worm, lacks comprehensive molecular data regarding its tissue-specific functions and reproductive mechanisms. In this study, we constructed the first multi-tissue transcriptome atlas of P. esculenta ,...

The RBMS1–SLC7A11 axis regulates ferroptosis susceptibility and lenvatinib sensitivity in hepatocellular carcinoma

Hepatocellular carcinoma remains a leading cause of cancer-related mortality worldwide. Although lenvatinib is widely deployed as a frontline systemic therapy for advanced disease, its clinical utility is frequently subverted by primary or adaptive non-responsiveness. Evasion of...

Association between neutrophil-to-HDL cholesterol ratio and diabetic nephropathy in adults with diabetes mellitus

Renal complications in diabetes impose substantial morbidity globally, yet early risk stratification remains challenging. The neutrophil-to-HDL cholesterol ratio (NHR) represents an integrated biomarker reflecting both immune activation and dyslipidemia, with neutrophilia promoti...

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

<title>Abstract</title> Abemaciclib is used for the treatment of breast cancer (BC) in clinics. The combination of abemaciclib and imperatorin or isoimperatorin has been studied <italic>in vitro</italic> and <italic>in vivo</italic> to explore the pharmacokinetics of Chinese herb...

The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

Background and Purpose Previous studies have highlighted the significance of the bile acid receptor TGR5 (also known as Takeda G protein‐coupled receptor 5) in regulating inflammation and mitochondrial homeostasis in various diseases, whereas the specific involvement of TGR5 in s...