Lishui Central Hospital

Bowstring reduction technique combined with cannulated screw fixation for Sanders type II intra-articular calcaneal fractures

Abstract Background Calcaneal fractures are the most common tarsal fractures, and displaced intra-articular fractures involving the posterior facet remain challenging for minimally invasive treatment because the achieved reduction is difficult to maintain. This study aimed to eva...

Association between coffee consumption and oral and pharyngeal cancers: a systematic review and meta-analysis

Oral and pharyngeal cancers are major contributors to global cancer-related morbidity and mortality, particularly in regions with high prevalence of tobacco, alcohol, and chewing-related exposures. Caffeine-containing beverages such as coffee and tea may influence carcinogenesis...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

What do master of nursing specialist students require during clinical practice? A qualitative study through the lens of workplace social capital networks

Advanced practice nurses (APNs) shoulder critical roles in the provision of advanced healthcare services. Master of Nursing Specialist (MNS) education, which aims to train specialized clinical talent, is the primary approach to cultivating APNs in China. MNS students are the focu...

The RBMS1–SLC7A11 axis regulates ferroptosis susceptibility and lenvatinib sensitivity in hepatocellular carcinoma

Hepatocellular carcinoma remains a leading cause of cancer-related mortality worldwide. Although lenvatinib is widely deployed as a frontline systemic therapy for advanced disease, its clinical utility is frequently subverted by primary or adaptive non-responsiveness. Evasion of...

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

<title>Abstract</title> Abemaciclib is used for the treatment of breast cancer (BC) in clinics. The combination of abemaciclib and imperatorin or isoimperatorin has been studied <italic>in vitro</italic> and <italic>in vivo</italic> to explore the pharmacokinetics of Chinese herb...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

The diagnostic role of SARS-CoV-2 in routine respiratory testing after policy adjustment: a real-world laboratory study integrating longitudinal PCR and respiratory pathogen testing workflow data

Since COVID-19 entered long-term management, SARS-CoV-2 has become increasingly integrated into routine respiratory diagnostics. However, longitudinal laboratory trends and its relative position within multiplex respiratory pathogen testing remain incompletely described in real-w...