Linyi People's Hospital

Anesthesia for Emergency Rigid Bronchoscopy in a Patient With Profound Hearing-Speech Impairment and Near-Total Tracheal Stenosis: A Case Report

Primary tracheal squamous cell carcinoma producing near-total fixed tracheal stenosis constitutes a catastrophic difficult airway scenario for emergency rigid bronchoscopy.Deaf-mute patients face added risks of agitation, tumor hemorrhage, and airway collapse due to complete loss...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

Effects of robot-assisted gait training on walking capacity and gross motor function in children with central nervous system impairments: a systematic review and meta-analysis predominantly based on cerebral palsy studies

Abstract Background Children with cerebral palsy (CP) and other central nervous system (CNS) impairments often have limitations in walking capacity and gross motor function. Robot-assisted gait training (RAGT) is increasingly used in pediatric rehabilitation, but existing evidenc...

Contribution of social determinants of health to racial disparities in metabolic dysfunction-associated steatotic liver disease among US adults

Abstract Background Racial and ethnic disparities in metabolic dysfunction-associated steatotic liver disease (MASLD) persist in the US population. We studied the impact of social determinants of health (SDOH) on the likelihood of developing MASLD and explored the contribution of...

Potential roles of short-chain fatty acids in chronic obstructive pulmonary disease from the gut-lung axis perspective: an exploratory trend summary and discussion on biological mechanisms based on current evidence

Short-chain fatty acids (SCFAs) have been proposed as mediators of the gut-lung axis in chronic obstructive pulmonary disease (COPD). However, the human evidence is limited and heterogeneous across disease states and specimen types. We therefore synthesized the available evidence...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Urolithin A mitigates doxorubicin-induced myocardial injury via suppression of ROS-driven apoptotic signaling.

BACKGROUND: were investigated. METHODS: protective mechanism. RESULTS: . CONCLUSION: by inhibiting ROS-driven apoptosis, which yields significant insights for combating DOX-mediated myocardial injury.

Early SOX9 Activation Primes Hippo– YAP / TAZ Rewiring During Glioblastoma Stemness Acquisition

Glioblastoma progression is driven by stemness acquisition and cellular plasticity, yet the temporal and spatial organization of these processes remains incompletely defined. In this study, single-cell RNA sequencing, pseudotime reconstruction, spatial transcriptomics, and in vit...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...